WTM2/YOR229W Protein Information

Standard Name	Wtm2p 1
Systematic Name	Yor229wp
ORF Classification	Verified
Description	Transcriptional modulator; involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats; WTM2 has a paralog, UME1, that arose from the whole genome duplication (1, 2, 3)
Name Description	WD repeat containing Transcriptional Modulator 1

Experimental Data
Molecules/cell	3750 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	467
Molecular Weight (Da)	51,951
Isoelectric Point (pI)	4.68

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Wtm2p (InterPro)
Physical Interactions	There are 33 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000138FA8 \| Q12206 MIPS: YOR229W NCBI: 1050781 \| 1420527 \| 2494903 \| 6324803 \| NP_014872.1 GenBank/EMBL/DDBJ: DAA10999.1 \| X92441 \| Z75137

Amino Acid Sequence (or in FASTA format)
1 MAKSKSSQGA SGARRKPAPS LYQHISSFKP QFSTRVDDVL HFSKTLTWRS 51 EIIPDKSKGT LTTSLLYSQG SDIYEIDTTL PLKTFYDDDD DDDNDDDDEE 101 GNGKTKSAAT PNPEYGDAFQ DVEGKPLRPK WIYQGETVAK MQYLESSDDS 151 TAIAMSKNGS LAWFRDEIKV PVHIVQEMMG PATRYSSIHS LTRPGSLAVS 201 DFDVSTNMDT VVKSQSNGYE EDSILKIIDN SDRPGDILRT VHVPGTNVAH 251 SVRFFNNHLF ASCSDDNILR FWDTRTADKP LWTLSEPKNG RLTSFDSSQV 301 TENLFVTGFS TGVIKLWDAR AVQLATTDLT HRQNGEEPIQ NEIAKLFHSG 351 GDSVVDILFS QTSATEFVTV GGTGNVYHWD MEYSFSRNDD DNEDEVRVAA 401 PEELQGQCLK FFHTGGTRRS SNQFGKRNTV ALHPVINDFV GTVDSDSLVT 451 AYKPFLASDF IGRGYDD*

Amino Acid Sequence (or in FASTA format)

       1  MAKSKSSQGA SGARRKPAPS LYQHISSFKP QFSTRVDDVL HFSKTLTWRS
      51  EIIPDKSKGT LTTSLLYSQG SDIYEIDTTL PLKTFYDDDD DDDNDDDDEE
     101  GNGKTKSAAT PNPEYGDAFQ DVEGKPLRPK WIYQGETVAK MQYLESSDDS
     151  TAIAMSKNGS LAWFRDEIKV PVHIVQEMMG PATRYSSIHS LTRPGSLAVS
     201  DFDVSTNMDT VVKSQSNGYE EDSILKIIDN SDRPGDILRT VHVPGTNVAH
     251  SVRFFNNHLF ASCSDDNILR FWDTRTADKP LWTLSEPKNG RLTSFDSSQV
     301  TENLFVTGFS TGVIKLWDAR AVQLATTDLT HRQNGEEPIQ NEIAKLFHSG
     351  GDSVVDILFS QTSATEFVTV GGTGNVYHWD MEYSFSRNDD DNEDEVRVAA
     401  PEELQGQCLK FFHTGGTRRS SNQFGKRNTV ALHPVINDFV GTVDSDSLVT
     451  AYKPFLASDF IGRGYDD*

external links for Wtm2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Wtm2p

1)	Pemberton LF and Blobel G (1997) Characterization of the Wtm proteins, a novel family of Saccharomyces cerevisiae transcriptional modulators with roles in meiotic regulation and silencing. Mol Cell Biol 17(8):4830-41
2)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3)	Tringe SG, et al. (2006) The WTM Genes in Budding Yeast Amplify Expression of the Stress-Inducible Gene RNR3. Genetics 174(3):1215-28
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41