GEP3/YOR205C Protein Information

Standard Name	Gep3p 1
Systematic Name	Yor205cp
Alias	Fmp38p 2 , Aim40p 3 , Mtg3p 4
ORF Classification	Verified
Description	Protein required for mitochondrial ribosome small subunit biogenesis; null mutant is defective in respiration and in maturation of 15S rRNA; protein is localized to the mitochondrial inner membrane; null mutant interacts synthetically with prohibitin (Phb1p) (1, 3, 4)
Name Description	GEnetic interactors of Prohibitins 1

Experimental Data
Molecules/cell	937 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	556
Molecular Weight (Da)	63,853
Isoelectric Point (pI)	10.07

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Gep3p (InterPro)
Physical Interactions	There are 2 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00000530A4 \| Q08622 MIPS: YOR205C NCBI: 1420481 \| 6324779 \| 74583740 \| NP_014848.1 \| NM_001183624.1 GenBank/EMBL/DDBJ: DAA10977.1 \| Z75113

Amino Acid Sequence (or in FASTA format)
1 MLNLCHALRG VRQFSCSVIV KVKCASCSIK LQDQDPSKPG YYTKPKSLPD 51 SKLNPDLQDL KYLLFSQDIQ LSKQATQNDP DLKTKRDLLL RVICKRCSNA 101 LHHNNYNPEE FPESTLNDIL NYVPRGSNVM HIVPFVEFPL HLDPNVLKRN 151 DLDTTLVLTK SDQVFKDKNA VSKKVPIFMK QFLKNTLRID SNKTFAISAL 201 KNWNISMFYN YFKNYTYLLG NPNVGKSTLI NTLLQKYLGY KVKIDSTGKI 251 NSPSEEVMQE AFTNPKNFFK IQAAGVSHIP NLTRSVQAYQ VGGKILFDLP 301 GYSTSTSRLR LEELIDERWL QRLRKTDLFN RKHIKQKTYE SMKGTSQGGC 351 YTVGGIFYLV PPKGSINQIV KYIPGPSKTF KNIEKGIDVF NSCNSSSGTH 401 PLSRYCGIKS VICEKSQYKR YAIPPFIGSI EIVLKDIGYI LLRTTGRYEF 451 KGLHEIWIPR GIQVGIREPL ENLIESGYQR YIETNGKESS CPRDRPIISS 501 LYEMAPDEAD TLNAVKKSYL EKTEKDLSAR RFVDDDPYDL VQHLEKKKNP 551 YWYYQW*

Amino Acid Sequence (or in FASTA format)

       1  MLNLCHALRG VRQFSCSVIV KVKCASCSIK LQDQDPSKPG YYTKPKSLPD
      51  SKLNPDLQDL KYLLFSQDIQ LSKQATQNDP DLKTKRDLLL RVICKRCSNA
     101  LHHNNYNPEE FPESTLNDIL NYVPRGSNVM HIVPFVEFPL HLDPNVLKRN
     151  DLDTTLVLTK SDQVFKDKNA VSKKVPIFMK QFLKNTLRID SNKTFAISAL
     201  KNWNISMFYN YFKNYTYLLG NPNVGKSTLI NTLLQKYLGY KVKIDSTGKI
     251  NSPSEEVMQE AFTNPKNFFK IQAAGVSHIP NLTRSVQAYQ VGGKILFDLP
     301  GYSTSTSRLR LEELIDERWL QRLRKTDLFN RKHIKQKTYE SMKGTSQGGC
     351  YTVGGIFYLV PPKGSINQIV KYIPGPSKTF KNIEKGIDVF NSCNSSSGTH
     401  PLSRYCGIKS VICEKSQYKR YAIPPFIGSI EIVLKDIGYI LLRTTGRYEF
     451  KGLHEIWIPR GIQVGIREPL ENLIESGYQR YIETNGKESS CPRDRPIISS
     501  LYEMAPDEAD TLNAVKKSYL EKTEKDLSAR RFVDDDPYDL VQHLEKKKNP
     551  YWYYQW*

external links for Gep3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Gep3p

1)	Osman C, et al. (2009) The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria. J Cell Biol 184(4):583-96
2)	Rehling, P., et al. (2004) personal communication
3)	Hess DC, et al. (2009) Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet 5(3):e1000407
4)	Paul MF, et al. (2012) The putative GTPase encoded by MTG3 functions in a novel pathway for regulating assembly of the small subunit of yeast mitochondrial ribosomes. J Biol Chem 287(29):24346-55
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41