DED1/YOR204W Protein Information Help

Standard Name Ded1p
Systematic Name Yor204wp
Alias Spp81p
ORF Classification Verified
Description ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase; required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility; DED1 has a paralog, DBP1, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description DEaD-box protein
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 604
Molecular Weight (Da) 65,552
Isoelectric Point (pI) 7.88

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ded1p (InterPro)
Physical Interactions There are 206 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001290F5 | P06634
MIPS: YOR204W
NCBI: 118411 | 1420479 | 3647 | 3781 | 398365729 | NP_014847.3 | NM_001183623.3
GenBank/EMBL/DDBJ: DAA10976.1 | X03245 | X57278 | Z75110
External Classifications EC: 3.6.1.- [Hydrolases acting on acid anhydrides in phosphorous-containing anhydrides]
EC: 3.6.4.13 [RNA helicase]
Amino Acid Sequence (or in FASTA format)
 
       1  MAELSEQVQN LSINDNNENG YVPPHLRGKP RSARNNSSNY NNNNGGYNGG
      51  RGGGSFFSNN RRGGYGNGGF FGGNNGGSRS NGRSGGRWID GKHVPAPRNE
     101  KAEIAIFGVP EDPNFQSSGI NFDNYDDIPV DASGKDVPEP ITEFTSPPLD
     151  GLLLENIKLA RFTKPTPVQK YSVPIVANGR DLMACAQTGS GKTGGFLFPV
     201  LSESFKTGPS PQPESQGSFY QRKAYPTAVI MAPTRELATQ IFDEAKKFTY
     251  RSWVKACVVY GGSPIGNQLR EIERGCDLLV ATPGRLNDLL ERGKISLANV
     301  KYLVLDEADR MLDMGFEPQI RHIVEDCDMT PVGERQTLMF SATFPADIQH
     351  LARDFLSDYI FLSVGRVGST SENITQKVLY VENQDKKSAL LDLLSASTDG
     401  LTLIFVETKR MADQLTDFLI MQNFRATAIH GDRTQSERER ALAAFRSGAA
     451  TLLVATAVAA RGLDIPNVTH VINYDLPSDV DDYVHRIGRT GRAGNTGLAT
     501  AFFNSENSNI VKGLHEILTE ANQEVPSFLK DAMMSAPGSR SNSRRGGFGR
     551  NNNRDYRKAG GASAGGWGSS RSRDNSFRGG SGWGSDSKSS GWGNSGGSNN
     601  SSWW*

external links for Ded1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA


YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Ded1p
1) Iost I, et al.  (1999) Ded1p, a DEAD-box protein required for translation initiation in Saccharomyces cerevisiae, is an RNA helicase. J Biol Chem 274(25):17677-83
2) Noueiry AO, et al.  (2000) A mutant allele of essential, general translation initiation factor DED1 selectively inhibits translation of a viral mRNA. Proc Natl Acad Sci U S A 97(24):12985-90
3) Johnstone O, et al.  (2005) Belle is a Drosophila DEAD-box protein required for viability and in the germ line. Dev Biol 277(1):92-101
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61