MRM1/YOR201C Protein Information

Standard Name	Mrm1p 1
Systematic Name	Yor201cp
Alias	Pet56p 2
ORF Classification	Verified
Description	Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA (2)
Name Description	Mitochondrial rRNA Methyltransferase 1

Experimental Data
Molecules/cell	2760 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	412
Molecular Weight (Da)	46,387
Isoelectric Point (pI)	9.95

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mrm1p (InterPro)
Physical Interactions	There are 19 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000005317E \| P25270 MIPS: YOR201C NCBI: 1346886 \| 1420475 \| 3779 \| 398365713 \| 431760 \| NP_014844.3 GenBank/EMBL/DDBJ: DAA10974.1 \| L19947 \| X03245 \| Z75107
External Classifications	EC: 2.1.1.- [Transferases transferring one-carbon groups methyltransferases]

Amino Acid Sequence (or in FASTA format)
1 MTSLTNAVFK RYLAVTPSAH QALKTRIKKK SSSFDKFFPQ QSNSRKKQWE 51 TLNEDKASWF KRKYAHVHAR EQDRAADPYG KKKAHVEKLK EIKNQAKLNQ 101 KSHKSKFQNK DIALKLMNDN PIFEYVYGTN SVYAALLNPS RNCHSRLLYH 151 GTIPSKFLQI VDELKVTTEL VDKHRLNLLT NYGVHNNIAL ETKPLQPVEI 201 AYLGDMDTSS AALSIHELGF NNENIPHELP YGTKTDAKKF PLGLYLDEIT 251 DPHNIGAIIR SAYFLGVDFI VMSRRNCSPL TPVVSKTSSG ALELLPIFYV 301 DKPLEFFTKS QEMGGWTFIT SHLANATSEK YTVGKTISMH DLNGLCNELP 351 VVLVVGNESQ GVRTNLKMRS DFFVEIPFGG IEKGNRAPEP IVDSLNVSVA 401 TALLIDNILT CK*

Amino Acid Sequence (or in FASTA format)

       1  MTSLTNAVFK RYLAVTPSAH QALKTRIKKK SSSFDKFFPQ QSNSRKKQWE
      51  TLNEDKASWF KRKYAHVHAR EQDRAADPYG KKKAHVEKLK EIKNQAKLNQ
     101  KSHKSKFQNK DIALKLMNDN PIFEYVYGTN SVYAALLNPS RNCHSRLLYH
     151  GTIPSKFLQI VDELKVTTEL VDKHRLNLLT NYGVHNNIAL ETKPLQPVEI
     201  AYLGDMDTSS AALSIHELGF NNENIPHELP YGTKTDAKKF PLGLYLDEIT
     251  DPHNIGAIIR SAYFLGVDFI VMSRRNCSPL TPVVSKTSSG ALELLPIFYV
     301  DKPLEFFTKS QEMGGWTFIT SHLANATSEK YTVGKTISMH DLNGLCNELP
     351  VVLVVGNESQ GVRTNLKMRS DFFVEIPFGG IEKGNRAPEP IVDSLNVSVA
     401  TALLIDNILT CK*

external links for Mrm1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Mrm1p

1)	Pintard L, et al. (2002) MRM2 encodes a novel yeast mitochondrial 21S rRNA methyltransferase. EMBO J 21(5):1139-47
2)	Sirum-Connolly K and Mason TL (1993) Functional requirement of a site-specific ribose methylation in ribosomal RNA. Science 262(5141):1886-9
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41