TUF1/YOR187W Protein Information

Standard Name	Tuf1p
Systematic Name	Yor187wp
ORF Classification	Verified
Description	Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans (1, 2) Also known as: tufM 1

Experimental Data
Molecules/cell	58500 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	437
Molecular Weight (Da)	47,972
Isoelectric Point (pI)	6.64

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Tuf1p (InterPro)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 15 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000129DE8 \| P02992 MIPS: YOR187W NCBI: 119216 \| 1420449 \| 6324761 \| NP_014830.1 \| NM_001183606.1 GenBank/EMBL/DDBJ: DAA10959.1 \| K00428 \| Z75095

Amino Acid Sequence (or in FASTA format)
1 MSALLPRLLT RTAFKASGKL LRLSSVISRT FSQTTTSYAA AFDRSKPHVN 51 IGTIGHVDHG KTTLTAAITK TLAAKGGANF LDYAAIDKAP EERARGITIS 101 TAHVEYETAK RHYSHVDCPG HADYIKNMIT GAAQMDGAII VVAATDGQMP 151 QTREHLLLAR QVGVQHIVVF VNKVDTIDDP EMLELVEMEM RELLNEYGFD 201 GDNAPIIMGS ALCALEGRQP EIGEQAIMKL LDAVDEYIPT PERDLNKPFL 251 MPVEDIFSIS GRGTVVTGRV ERGNLKKGEE LEIVGHNSTP LKTTVTGIEM 301 FRKELDSAMA GDNAGVLLRG IRRDQLKRGM VLAKPGTVKA HTKILASLYI 351 LSKEEGGRHS GFGENYRPQM FIRTADVTVV MRFPKEVEDH SMQVMPGDNV 401 EMECDLIHPT PLEVGQRFNI REGGRTVGTG LITRIIE*

Amino Acid Sequence (or in FASTA format)

       1  MSALLPRLLT RTAFKASGKL LRLSSVISRT FSQTTTSYAA AFDRSKPHVN
      51  IGTIGHVDHG KTTLTAAITK TLAAKGGANF LDYAAIDKAP EERARGITIS
     101  TAHVEYETAK RHYSHVDCPG HADYIKNMIT GAAQMDGAII VVAATDGQMP
     151  QTREHLLLAR QVGVQHIVVF VNKVDTIDDP EMLELVEMEM RELLNEYGFD
     201  GDNAPIIMGS ALCALEGRQP EIGEQAIMKL LDAVDEYIPT PERDLNKPFL
     251  MPVEDIFSIS GRGTVVTGRV ERGNLKKGEE LEIVGHNSTP LKTTVTGIEM
     301  FRKELDSAMA GDNAGVLLRG IRRDQLKRGM VLAKPGTVKA HTKILASLYI
     351  LSKEEGGRHS GFGENYRPQM FIRTADVTVV MRFPKEVEDH SMQVMPGDNV
     401  EMECDLIHPT PLEVGQRFNI REGGRTVGTG LITRIIE*

external links for Tuf1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Tuf1p

1)	Nagata S, et al. (1983) Molecular cloning and sequence determination of the nuclear gene coding for mitochondrial elongation factor Tu of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 80(20):6192-6
2)	Chiron S, et al. (2005) Mitochondrial translation: elongation factor tu is essential in fission yeast and depends on an exchange factor conserved in humans but not in budding yeast. Genetics 169(4):1891-901
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41