SEY1/YOR165W Protein Information Help

Standard Name Sey1p 1
Systematic Name Yor165wp
ORF Classification Verified
Description Dynamin-like GTPase that mediates homotypic ER fusion; has a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; functional ortholog of the human atlastin ATL1, defects in which cause a form of the human disease hereditary spastic paraplegia; homolog of Arabidopsis RHD3 (1, 2, 3)
Name Description Synthetic Enhancement of YOP1 1
Experimental Data
Molecules/cell 2270 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 776
Molecular Weight (Da) 89,432
Isoelectric Point (pI) 5.03

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Sey1p (InterPro)
Transmembrane Domains There are 2 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 18 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006C037 | Q99287
MIPS: YOR165W
NCBI: 1293726 | 1420407 | 6324739 | 73919313 | NP_014808.1
GenBank/EMBL/DDBJ: DAA10939.1 | U55021 | Z75073
External Classifications EC: 3.6.5.- [Hydrolases, Acting on GTP; involved in cellular and subcellular movement]
Amino Acid Sequence (or in FASTA format)
 
       1  MADRPAIQLI DEEKEFHQSA LQYFQQCIGN RDVGLDYHVI SVFGSQSSGK
      51  STLLNVLFNT NFDTMDAQVK RQQTTKGIWL AHTKQVNTTI EIDNDRPDIF
     101  VLDVEGSDGS ERGEDQDFER KAALFAIAVS EVLIVNMWEQ QIGLYQGNNM
     151  ALLKTVFEVN LSLFGKNDND HKVLLLFVIR DHVGVTPLSS LSDSVTRELE
     201  KIWTELSKPA GCEGSSLYDY FDLKFVGLAH KLLQEDKFTQ DVKKLGDSFV
     251  MKGTENYYFK PQYHHRLPLD GWTMYAENCW DQIERNKDLD LPTQQILVAR
     301  FKTEEISNEA LEEFISKYDE SIAPLKGNLG SLTSQLVKLK EECLTKYDEQ
     351  ASRYARNVYM EKREALNTKL NSHISGTINE FLESLMEKLW DDLKLEVSSR
     401  DKATTSFVES VAAGKSKIEK EFNESMETFK KLGLLISNEE ITCKFSDDIE
     451  ERIKQLRDAE LKAKIGRIKK NLVPELKDHV IHLLSHPSKK VWDDIMNDFE
     501  STIKDNISAY QVEKDKYDFK IGLSESENAK IYKNIRILAW RTLDTTVHDY
     551  LKIDTIVSIL RDRFEDVFRY DAEGSPRLWK TEEEIDGAFR VAKEHALEVF
     601  EVLSLAVTSD NVEIIPDVPM AEEESGEDNE IYRDNEGVFH SRRFAHILTE
     651  LQKENVLDQF RRQINITVLD SKRSIITTRT HIPPWIYVLL AVLGWNEFVA
     701  VIRNPLFVTL TLILGATFFV IHKFGLWGPV VNVVQSAVGE TRTAIKDKLR
     751  QFVVEDHEVK ESFEMKDFSK NEQKEK*

external links for Sey1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB GeneMANIA

YOGY


References cited on this page View Complete Literature Guide for Sey1p
1) Brands A and Ho TH  (2002) Function of a plant stress-induced gene, HVA22. Synthetic enhancement screen with its yeast homolog reveals its role in vesicular traffic. Plant Physiol 130(3):1121-31
2) Hu J, et al.  (2009) A class of dynamin-like GTPases involved in the generation of the tubular ER network. Cell 138(3):549-61
3) Anwar K, et al.  (2012) The dynamin-like GTPase Sey1p mediates homotypic ER fusion in S. cerevisiae. J Cell Biol 197(2):209-17
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41