MTR10/YOR160W Protein Information

Standard Name	Mtr10p
Systematic Name	Yor160wp
Alias	Kap111p
ORF Classification	Verified
Description	Nuclear import receptor; mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs; relocalizes from cytoplasm to the nuclear periphery upon DNA replication stress (1, 2, 3, 4, 5)
Name Description	Mrna TRansport defective 6

Experimental Data
Molecules/cell	6340 7

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	972
Molecular Weight (Da)	110,744
Isoelectric Point (pI)	4.51

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mtr10p (InterPro)
Physical Interactions	There are 31 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052F60 \| Q99189 MIPS: YOR160W NCBI: 1293720 \| 1420397 \| 2498597 \| 6324734 \| NP_014803.1 GenBank/EMBL/DDBJ: DAA10933.1 \| U55020 \| Z75068

Amino Acid Sequence (or in FASTA format)
1 MDNLQVSDIE TALQCISSTA SQDDKNKALQ FLEQFQRSTV AWSICNEILS 51 KEDPTNALLE LNIFAAQTLR NKVTYDLSQL ENNLPQFKDS LLTLLLSHNQ 101 KLIITQLNVA LARLAIQFLE WQNPIFEIIS LLNSSPSILL NFLRILPEET 151 LDIASTSLTE VEFNSRIHEL IDPIAEDVLK FLVSCIDLLQ NTDGNSSSSI 201 SLEQILRCLN SWSYEFPVEQ LLTVQPLINL VFETISNGNE SDMEAFDSAI 251 DCLCVILRES RDTTNEQLIS ALFHQLMLLQ EKLLPTLFTD HPLNDEYDDD 301 LLEGMTRLFV EAGEAWSVVI SKNPDFFKPM VLVLLMLTCK NEDLDVVSYT 351 FPFWFNFKQS LVLPRYQESR KAYSDIFVKL INGIITHLQY PSGQFSSKEE 401 EDKFKDFRYH MGDVLKDCTA VVGTSEALSQ PLIRIKSAIE NNNSWQIMEA 451 PLFSLRTMAK EISLTENTIL PEIIKIICNL PEQAKIRYAS TLVLGRYTEW 501 TAKHPELLEV QLQYIFNGFQ LHEGSSDMQS IITASSHALM FFCSDCSKLL 551 VGYIDQLINF FLNVQSSIDI ESQFELCQGL SAVINNQPEA KVSVIFQKLV 601 DDNLRQIEAL IPQWKANPTL LAPQIADKID LLYALFEELK PRYNYPQQGS 651 EPLLPRIEFI WKALRTLLVD AGAMTDSIIV ERVAKLLRRI FERFHVFCEP 701 ILPSVAEFLI QGYLTTGFGS YLWCSGSLIV IFGDDESFPI SPSLKDAVWK 751 FALSQCETFI LNFNKFDKLQ LNDYHEAIID FFSLISDLIM FYPGAFLNST 801 ELLGPVLNVA LECVNKLDNY DAYICILRCL DDIISWGFKT PPISTVSIEI 851 VPDEWRKQVI NEVVIAHGNQ LILVLFIGLV TTFENTAHSD AISCIVKCLR 901 ILTEANNNDA TICIDWIYKV VEQLGQVTLN ERDNLAKAVV EGLNSKDYRK 951 VREGIRAFVG WYSRKNINSR FE*

Amino Acid Sequence (or in FASTA format)

       1  MDNLQVSDIE TALQCISSTA SQDDKNKALQ FLEQFQRSTV AWSICNEILS
      51  KEDPTNALLE LNIFAAQTLR NKVTYDLSQL ENNLPQFKDS LLTLLLSHNQ
     101  KLIITQLNVA LARLAIQFLE WQNPIFEIIS LLNSSPSILL NFLRILPEET
     151  LDIASTSLTE VEFNSRIHEL IDPIAEDVLK FLVSCIDLLQ NTDGNSSSSI
     201  SLEQILRCLN SWSYEFPVEQ LLTVQPLINL VFETISNGNE SDMEAFDSAI
     251  DCLCVILRES RDTTNEQLIS ALFHQLMLLQ EKLLPTLFTD HPLNDEYDDD
     301  LLEGMTRLFV EAGEAWSVVI SKNPDFFKPM VLVLLMLTCK NEDLDVVSYT
     351  FPFWFNFKQS LVLPRYQESR KAYSDIFVKL INGIITHLQY PSGQFSSKEE
     401  EDKFKDFRYH MGDVLKDCTA VVGTSEALSQ PLIRIKSAIE NNNSWQIMEA
     451  PLFSLRTMAK EISLTENTIL PEIIKIICNL PEQAKIRYAS TLVLGRYTEW
     501  TAKHPELLEV QLQYIFNGFQ LHEGSSDMQS IITASSHALM FFCSDCSKLL
     551  VGYIDQLINF FLNVQSSIDI ESQFELCQGL SAVINNQPEA KVSVIFQKLV
     601  DDNLRQIEAL IPQWKANPTL LAPQIADKID LLYALFEELK PRYNYPQQGS
     651  EPLLPRIEFI WKALRTLLVD AGAMTDSIIV ERVAKLLRRI FERFHVFCEP
     701  ILPSVAEFLI QGYLTTGFGS YLWCSGSLIV IFGDDESFPI SPSLKDAVWK
     751  FALSQCETFI LNFNKFDKLQ LNDYHEAIID FFSLISDLIM FYPGAFLNST
     801  ELLGPVLNVA LECVNKLDNY DAYICILRCL DDIISWGFKT PPISTVSIEI
     851  VPDEWRKQVI NEVVIAHGNQ LILVLFIGLV TTFENTAHSD AISCIVKCLR
     901  ILTEANNNDA TICIDWIYKV VEQLGQVTLN ERDNLAKAVV EGLNSKDYRK
     951  VREGIRAFVG WYSRKNINSR FE*

external links for Mtr10p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Mtr10p

1)	Pemberton LF, et al. (1997) A distinct and parallel pathway for the nuclear import of an mRNA-binding protein. J Cell Biol 139(7):1645-53
2)	Senger B, et al. (1998) Mtr10p functions as a nuclear import receptor for the mRNA-binding protein Npl3p. EMBO J 17(8):2196-207
3)	Windgassen M, et al. (2004) Yeast shuttling SR proteins Npl3p, Gbp2p, and Hrb1p are part of the translating mRNPs, and Npl3p can function as a translational repressor. Mol Cell Biol 24(23):10479-91
4)	Murthi A, et al. (2010) Regulation of tRNA Bidirectional Nuclear-Cytoplasmic Trafficking in Saccharomyces cerevisiae. Mol Biol Cell 21(4):639-49
5)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
6)	Kadowaki T, et al. (1994) Isolation and characterization of Saccharomyces cerevisiae mRNA transport-defective (mtr) mutants. J Cell Biol 126(3):649-59
7)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41