ELG1/YOR144C Protein Information Help

Standard Name Elg1p 1
Systematic Name Yor144cp
Alias Rtt110p
ORF Classification Verified
Description Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis; required for PCNA (Pol30p) unloading during DNA replication (1, 2, 3, 4, 5, 6)
Name Description Enhanced Level of Genomic instability 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 791
Molecular Weight (Da) 91,261
Isoelectric Point (pI) 6.98

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Elg1p (InterPro)
Physical Interactions There are 54 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000053104 | Q12050
MIPS: YOR144C
NCBI: 1164987 | 1293705 | 1420366 | 2326815 | 398365367 | 59799383 | NP_014787.3
GenBank/EMBL/DDBJ: DAA10918.1 | U55020 | X94335 | Z75052 | Z75053
Amino Acid Sequence (or in FASTA format)
 
       1  MKRHVSLSDI LTGNKRKVRR QDALQITIDD ENDTESGTFD ARTAKHDDSS
      51  VIFLNHSVVK PIEAVSTNHK SAKEFLMTKR TKEKCDDDDD DLIVISDKSP
     101  KSETNCSKIA LSQEHEDDIS IISTSRIKSS LLNERASKIK NFLKHETTDT
     151  FKRLNSISKL NEIEPPLPLH QSIFPVGDKE LSDRSVDIPL PFRTIPPLNH
     201  NFLPSDYESL KDKNSASCIP VRYQAPVLLG TNIKRNTTLT WPQLFKPVTL
     251  KQVLIEPKLK LRIKNWIETS FHTLEKPTLR NRLLNRINPN KQQGSGDELA
     301  NFIVPDLEED ENLRPDFYRN GEANSSLSEF VPLMILHGNS IGKKTLIQTI
     351  MREIAGDDNS YQIYEVNSNM NRSKKDLLDI LLDFTTTHYV KDSSKRKSDY
     401  GLVLFNDVDV LFKEHDRGYW AMISKLCEFS RRPLVLTCKD LSLVPSELIA
     451  LASEQNSLFH TKKISTSTVY AFLTKYLKSL EIEVCDDWLR DVVKQNNADI
     501  RKCLMHLQFW CVDTEADLIS SKNRLPVLTS TLGSSVKDIS QLTDLLSIND
     551  VIGQATLNRS MVRQEIDSTT MTPEKVNTFQ DQNLDDEMKL KFDYVIDYKL
     601  HLNDPNRQPL LPFELNIYQH IQEQLEARYS YVREANHRLD NEYLVNRFKK
     651  MTESTLNFLA SRIPKYDHLQ SARRTRNSKK ISDILNQFKG IYNDETLNEN
     701  AEIDLLSATT QQIKAEINPF VFEIAKSDAN VKNENKQIFE LHSENVSERR
     751  YKDLVYQLSQ EGVLKNVWFN ADPSIVVRKW EHLHSGFSKN K*

external links for Elg1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Elg1p
1) Ben-Aroya S, et al.  (2003) ELG1, a yeast gene required for genome stability, forms a complex related to replication factor C. Proc Natl Acad Sci U S A 100(17):9906-11
2) Bellaoui M, et al.  (2003) Elg1 forms an alternative RFC complex important for DNA replication and genome integrity. EMBO J 22(16):4304-13
3) Kanellis P, et al.  (2003) Elg1 forms an alternative PCNA-interacting RFC complex required to maintain genome stability. Curr Biol 13(18):1583-95
4) Ogiwara H, et al.  (2007) Role of Elg1 protein in double strand break repair. Nucleic Acids Res 35(2):353-62
5) Davidson MB and Brown GW  (2008) The N- and C-termini of Elg1 contribute to the maintenance of genome stability. DNA Repair (Amst) 7(8):1221-32
6) Kubota T, et al.  (2013) The Elg1 Replication Factor C-like Complex Functions in PCNA Unloading during DNA Replication. Mol Cell 50(2):273-80