LSC1/YOR142W Protein Information

Standard Name	Lsc1p 1
Systematic Name	Yor142wp
ORF Classification	Verified
Description	Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated (1, 2)
Name Description	Ligase of Succinyl-CoA 1

Experimental Data
Molecules/cell	18400 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	329
Molecular Weight (Da)	35,032
Isoelectric Point (pI)	8.73

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Lsc1p (InterPro)
Physical Interactions	There are 17 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013618F \| P53598 MIPS: YOR142W NCBI: 1164984 \| 1420358 \| 1711576 \| 398365347 \| NP_014785.3 GenBank/EMBL/DDBJ: DAA10914.1 \| X94335 \| Z75050
External Classifications	EC: 6.2.1.4 [Succinate--CoA ligase (GDP-forming)] EC: 6.2.1.5 [Succinate--CoA ligase (ADP-forming)]

Amino Acid Sequence (or in FASTA format)
1 MLRSTVSKAS LKICRHFHRE SIPYDKTIKN LLLPKDTKVI FQGFTGKQGT 51 FHASISQEYG TNVVGGTNPK KAGQTHLGQP VFASVKDAIK ETGATASAIF 101 VPPPIAAAAI KESIEAEIPL AVCITEGIPQ HDMLYIAEML QTQDKTRLVG 151 PNCPGIINPA TKVRIGIQPP KIFQAGKIGI ISRSGTLTYE AVQQTTKTDL 201 GQSLVIGMGG DAFPGTDFID ALKLFLEDET TEGIIMLGEI GGKAEIEAAQ 251 FLKEYNFSRS KPMPVASFIA GTVAGQMKGV RMGHSGAIVE GSGTDAESKK 301 QALRDVGVAV VESPGYLGQA LLDQFAKFK*

Amino Acid Sequence (or in FASTA format)

       1  MLRSTVSKAS LKICRHFHRE SIPYDKTIKN LLLPKDTKVI FQGFTGKQGT
      51  FHASISQEYG TNVVGGTNPK KAGQTHLGQP VFASVKDAIK ETGATASAIF
     101  VPPPIAAAAI KESIEAEIPL AVCITEGIPQ HDMLYIAEML QTQDKTRLVG
     151  PNCPGIINPA TKVRIGIQPP KIFQAGKIGI ISRSGTLTYE AVQQTTKTDL
     201  GQSLVIGMGG DAFPGTDFID ALKLFLEDET TEGIIMLGEI GGKAEIEAAQ
     251  FLKEYNFSRS KPMPVASFIA GTVAGQMKGV RMGHSGAIVE GSGTDAESKK
     301  QALRDVGVAV VESPGYLGQA LLDQFAKFK*

external links for Lsc1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Lsc1p

1)	Przybyla-Zawislak B, et al. (1998) Genes of succinyl-CoA ligase from Saccharomyces cerevisiae. Eur J Biochem 258(2):736-43
2)	Reinders J, et al. (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41