SFL1/YOR140W Protein Information Help

Standard Name Sfl1p 1
Systematic Name Yor140wp
ORF Classification Verified
Description Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p (1, 2, 3, 4, 5)
Name Description Suppressor gene for FLocculation 1
Experimental Data
Molecules/cell 1040 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 766
Molecular Weight (Da) 83,344
Isoelectric Point (pI) 9.13

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Sfl1p (InterPro)
Physical Interactions There are 18 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000017459F | P20134
MIPS: YOR140W
NCBI: 1164982 | 1420354 | 2506540 | 347595781 | 398365337 | NP_014783.4
GenBank/EMBL/DDBJ: DAA10912.2 | X94335 | Z75047
Amino Acid Sequence (or in FASTA format)
 
       1  MSEEETVSAP APASTPAPAG TDVGSGGAAA GIANAGAEGG DGAEDVKKHG
      51  SKMLVGPRPP QNAIFIHKLY QILEDESLHD LIWWTPSGLS FMIKPVERFS
     101  KALATYFKHT NITSFVRQLN IYGFHKVSHD HSSNDANSGD DANTNDDSNT
     151  HDDNSGNKNS SGDENTGGGV QEKEKSNPTK IWEFKHSSGI FKKGDIEGLK
     201  HIKRRASSRN NSSINSRKNS SNQNYDIDSG ARVRPSSIQD PSTSSNSFGN
     251  FVPQIPGANN SIPEYFNNSH VTYENANHAP LESNNPEMQE QNRPPNFQDE
     301  TLKHLKEINF DMVKIIESMQ HFISLQHSFC SQSFTFKNVS KKKSENIVKD
     351  HQKQLQAFES DMLTFKQHVM SRAHRTIDSL CAVNAAATAA SVAPAPAPTS
     401  TSAYAPKSQY EMMVPPGNQY VPQKSSSTTN IPSRFNTASV PPSQLFVQYQ
     451  PQSQQHVTYA KQPAHVPNFI NQPIPIQQLP PQYADTFSTP QMMHNPFASK
     501  NNNKPGNTKR TNSVLMDPLT PAASVGVQGP LNYPIMNINP SVRDYNKPVP
     551  QNMAPSPIYP INEPTTRLYS QPKMRSLGST SSLPNDRRNS PLKLTPRSSL
     601  NEDSLYPKPR NSLKSSISGT SLSSSFTLVA NNPAPIRYSQ QGLLRSLNKA
     651  ANCAPDSVTP LDSSVLTGPP PKNMDNLPAV SSNLINSPMN VEHSSSLSQA
     701  EPAPQIELPQ PSLPTTSTTK NTGEADNSKR KGSGVYSLLN QEDSSTSSAD
     751  PKTEDKAAPA LKKVKM*

external links for Sfl1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Sfl1p
1) Fujita A, et al.  (1989) Domains of the SFL1 protein of yeasts are homologous to Myc oncoproteins or yeast heat-shock transcription factor. Gene 85(2):321-8
2) Robertson LS and Fink GR  (1998) The three yeast A kinases have specific signaling functions in pseudohyphal growth. Proc Natl Acad Sci U S A 95(23):13783-7
3) Conlan RS and Tzamarias D  (2001) Sfl1 functions via the co-repressor Ssn6-Tup1 and the cAMP-dependent protein kinase Tpk2. J Mol Biol 309(5):1007-15
4) Pan X and Heitman J  (2002) Protein kinase A operates a molecular switch that governs yeast pseudohyphal differentiation. Mol Cell Biol 22(12):3981-93
5) Ansanay Galeote V, et al.  (2007) Sfl1p acts as an activator of the HSP30 gene in Saccharomyces cerevisiae. Curr Genet 52(2):55-63
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41