IDH2/YOR136W Protein Information

Standard Name	Idh2p
Systematic Name	Yor136wp
ORF Classification	Verified
Description	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated (1, 2)
Name Description	Isocitrate DeHydrogenase

Experimental Data
Molecules/cell	43100 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	369
Molecular Weight (Da)	39,739
Isoelectric Point (pI)	9.15

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Idh2p (InterPro)
Physical Interactions	There are 55 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052F29 \| P28241 MIPS: YOR136W NCBI: 1050815 \| 1164979 \| 124159 \| 1420347 \| 167013431 \| 167013433 \| 167013435 \| 167013437 \| 167013439 \| 167013441 \| 167013443 \| 167013445 \| 167013447 \| 167013449 \| 167013451 \| 167013453 \| 167013455 \| 167013457 \| 167013459 \| 167013461 \| 167013463 \| 167013465 \| 167013467 \| 167013469 \| 171747 \| 6324709 \| NP_014779.1 GenBank/EMBL/DDBJ: DAA10909.1 \| M74131 \| X90518 \| X94335 \| Z75043
External Classifications	EC: 1.1.1.41 [Isocitrate dehydrogenase (NAD(+))]

Amino Acid Sequence (or in FASTA format)
1 MLRNTFFRNT SRRFLATVKQ PSIGRYTGKP NPSTGKYTVS FIEGDGIGPE 51 ISKSVKKIFS AANVPIEWES CDVSPIFVNG LTTIPDPAVQ SITKNLVALK 101 GPLATPIGKG HRSLNLTLRK TFGLFANVRP AKSIEGFKTT YENVDLVLIR 151 ENTEGEYSGI EHIVCPGVVQ SIKLITRDAS ERVIRYAFEY ARAIGRPRVI 201 VVHKSTIQRL ADGLFVNVAK ELSKEYPDLT LETELIDNSV LKVVTNPSAY 251 TDAVSVCPNL YGDILSDLNS GLSAGSLGLT PSANIGHKIS IFEAVHGSAP 301 DIAGQDKANP TALLLSSVMM LNHMGLTNHA DQIQNAVLST IASGPENRTG 351 DLAGTATTSS FTEAVIKRL*

Amino Acid Sequence (or in FASTA format)

       1  MLRNTFFRNT SRRFLATVKQ PSIGRYTGKP NPSTGKYTVS FIEGDGIGPE
      51  ISKSVKKIFS AANVPIEWES CDVSPIFVNG LTTIPDPAVQ SITKNLVALK
     101  GPLATPIGKG HRSLNLTLRK TFGLFANVRP AKSIEGFKTT YENVDLVLIR
     151  ENTEGEYSGI EHIVCPGVVQ SIKLITRDAS ERVIRYAFEY ARAIGRPRVI
     201  VVHKSTIQRL ADGLFVNVAK ELSKEYPDLT LETELIDNSV LKVVTNPSAY
     251  TDAVSVCPNL YGDILSDLNS GLSAGSLGLT PSANIGHKIS IFEAVHGSAP
     301  DIAGQDKANP TALLLSSVMM LNHMGLTNHA DQIQNAVLST IASGPENRTG
     351  DLAGTATTSS FTEAVIKRL*

external links for Idh2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Idh2p

1)	Cupp JR and McAlister-Henn L (1991) NAD(+)-dependent isocitrate dehydrogenase. Cloning, nucleotide sequence, and disruption of the IDH2 gene from Saccharomyces cerevisiae. J Biol Chem 266(33):22199-205
2)	Reinders J, et al. (2007) Profiling phosphoproteins of yeast mitochondria reveals a role of phosphorylation in assembly of the ATP synthase. Mol Cell Proteomics 6(11):1896-906
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41