BAG7/YOR134W Protein Information

Standard Name	Bag7p
Systematic Name	Yor134wp
ORF Classification	Verified
Description	Rho GTPase activating protein (RhoGAP); stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p; BAG7 has a paralog, SAC7, that arose from the whole genome duplication (1, 2, 3)

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	409
Molecular Weight (Da)	46,216
Isoelectric Point (pI)	7.57

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Bag7p (InterPro)
Physical Interactions	There are 6 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006C1D8 \| Q12128 MIPS: YOR134W NCBI: 1050814 \| 1164978 \| 1420344 \| 398365313 \| 46395694 \| NP_014777.3 \| NM_001183553.3 GenBank/EMBL/DDBJ: DAA10908.1 \| X90518 \| X94335 \| Z75042

Amino Acid Sequence (or in FASTA format)
1 MFNMNLLSTP SSEEGSPQNR SSSMSSVEGK KDRDTFTNLQ NEFDGKVFGV 51 SLEESLKVAQ EEVIIQKSTN EIGSIPVVIA KSGKYLKENA LDTTGIFRIA 101 GSNKRVRELQ AVFSKPPDYG RKFEGWCDFN VHDIATLLKR YLNSLSEPLV 151 PLALYDIFRN PILENPKINE HKEQIIKDYE DIYMLLPQQN RHLILYLAAL 201 LNLFARNEKK NLMSASNLAA IVQPSLLSHP KDEMCPKEYE ASRTVIEFLI 251 LHASDIIPNT EKANKDTMPH AGTVAKFNNI TVPEMAIDSD EEDFVHPSID 301 DHMLPRSRAL SDSNNFTIHH HHHHHHALFP SPIDFDNNGL SVPRSFKGRT 351 LSAESLSPRL SKLLGNVGNS SNTGIKDPTE RVPRGEHKTK HKQRQSWLRR 401 LTSPSRTQP*

Amino Acid Sequence (or in FASTA format)

       1  MFNMNLLSTP SSEEGSPQNR SSSMSSVEGK KDRDTFTNLQ NEFDGKVFGV
      51  SLEESLKVAQ EEVIIQKSTN EIGSIPVVIA KSGKYLKENA LDTTGIFRIA
     101  GSNKRVRELQ AVFSKPPDYG RKFEGWCDFN VHDIATLLKR YLNSLSEPLV
     151  PLALYDIFRN PILENPKINE HKEQIIKDYE DIYMLLPQQN RHLILYLAAL
     201  LNLFARNEKK NLMSASNLAA IVQPSLLSHP KDEMCPKEYE ASRTVIEFLI
     251  LHASDIIPNT EKANKDTMPH AGTVAKFNNI TVPEMAIDSD EEDFVHPSID
     301  DHMLPRSRAL SDSNNFTIHH HHHHHHALFP SPIDFDNNGL SVPRSFKGRT
     351  LSAESLSPRL SKLLGNVGNS SNTGIKDPTE RVPRGEHKTK HKQRQSWLRR
     401  LTSPSRTQP*

external links for Bag7p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Bag7p

1)	Roumanie O, et al. (2001) Functional characterization of the Bag7, Lrg1 and Rgd2 RhoGAP proteins from Saccharomyces cerevisiae. FEBS Lett 506(2):149-56
2)	Schmidt A, et al. (2002) The RHO1-GAPs SAC7, BEM2 and BAG7 control distinct RHO1 functions in Saccharomyces cerevisiae. Mol Microbiol 45(5):1433-41
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61