ADE2/YOR128C Protein Information Help

ADE2 BASIC PROTEIN INFORMATION

Standard Name Ade2p 1
Systematic Name Yor128cp
ORF Classification Verified
Description Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine ( 2 )
Name Description ADEnine requiring 1
Experimental Data
Molecules/cell 5410 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 571
Molecular Weight (Da) 62,339
Isoelectric Point (pI) 7.31

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Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ade2p (InterPro)
Physical Interactions There are 11 total curated physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | PSI-BLAST | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
Secondary Structure Prediction GCG:PepPlot | GCG:PepStruct | GCG:Helical Wheel
External Sequence Databases EBI: P21264 | UPI000011EE15
MIPS: YOR128C
NCBI: NP_014771.1 | 6324702
GenBank/EMBL/DDBJ: AAA34401.1 | AAA34407.1 | CAA62125.1 | CAA64047.1 | CAA99327.1
External Classifications EC: 4.1.1.21 [Phosphoribosylaminoimidazole carboxylase]
Amino Acid Sequence (or in FASTA format)
 
       1  MDSRTVGILG GGQLGRMIVE AANRLNIKTV ILDAENSPAK QISNSNDHVN
      51  GSFSNPLDIE KLAEKCDVLT IEIEHVDVPT LKNLQVKHPK LKIYPSPETI
     101  RLIQDKYIQK EHLIKNGIAV TQSVPVEQAS ETSLLNVGRD LGFPFVLKSR
     151  TLAYDGRGNF VVKNKEMIPE ALEVLKDRPL YAEKWAPFTK ELAVMIVRSV
     201  NGLVFSYPIV ETIHKDNICD LCYAPARVPD SVQLKAKLLA ENAIKSFPGC
     251  GIFGVEMFYL ETGELLINEI APRPHNSGHY TIDACVTSQF EAHLRSILDL
     301  PMPKNFTSFS TITTNAIMLN VLGDKHTKDK ELETCERALA TPGSSVYLYG
     351  KESRPNRKVG HINIIASSMA ECEQRLNYIT GRTDIPIKIS VAQKLDLEAM
     401  VKPLVGIIMG SDSDLPVMSA ACAVLKDFGV PFEVTIVSAH RTPHRMSAYA
     451  ISASKRGIKT IIAGAGGAAH LPGMVAAMTP LPVIGVPVKG SCLDGVDSLH
     501  SIVQMPRGVP VATVAINNST NAALLAVRLL GAYDSSYTTK MEQFLLKQEE
     551  EVLVKAQKLE TVGYEAYLEN K*

EXTERNAL LINKS for Ade2p

Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB (UMich)
Ashbya (AGD) BOND GPMdb (Mass Spec.) YGAC Triples
Candida (CGD) BioPIXIE MIPS
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB DIP PhosphoPep Database
YOGY
YeastRC Structure Prediction (Seattle)

REFERENCES CITED ON THIS PAGE [View Complete Literature Guide for Ade2p ]

1) Dorfman BZ  (1969) The isolation of adenylosuccinate synthetase mutants in yeast by selection for constitutive behavior in pigmented strains. Genetics 61(2):377-89
2) Jones EW and Fink GR  (1982) "Regulation of amino acid and nucleotide biosynthesis in yeast." Pp.181-299 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41