ADE2/YOR128C Protein Information

Standard Name	Ade2p 1
Systematic Name	Yor128cp
ORF Classification	Verified
Description	Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine (2)
Name Description	ADEnine requiring 1

Experimental Data
Molecules/cell	5410 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	571
Molecular Weight (Da)	62,339
Isoelectric Point (pI)	7.31

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ade2p (InterPro)
Physical Interactions	There are 13 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000011EE15 \| P21264 MIPS: YOR128C NCBI: 1050830 \| 1164972 \| 131630 \| 1420332 \| 171003 \| 171017 \| 398365279 \| NP_014771.3 GenBank/EMBL/DDBJ: DAA10902.1 \| M58324 \| M59824 \| X90518 \| X94335 \| Z75036
External Classifications	EC: 4.1.1.21 [Phosphoribosylaminoimidazole carboxylase]

Amino Acid Sequence (or in FASTA format)
1 MDSRTVGILG GGQLGRMIVE AANRLNIKTV ILDAENSPAK QISNSNDHVN 51 GSFSNPLDIE KLAEKCDVLT IEIEHVDVPT LKNLQVKHPK LKIYPSPETI 101 RLIQDKYIQK EHLIKNGIAV TQSVPVEQAS ETSLLNVGRD LGFPFVLKSR 151 TLAYDGRGNF VVKNKEMIPE ALEVLKDRPL YAEKWAPFTK ELAVMIVRSV 201 NGLVFSYPIV ETIHKDNICD LCYAPARVPD SVQLKAKLLA ENAIKSFPGC 251 GIFGVEMFYL ETGELLINEI APRPHNSGHY TIDACVTSQF EAHLRSILDL 301 PMPKNFTSFS TITTNAIMLN VLGDKHTKDK ELETCERALA TPGSSVYLYG 351 KESRPNRKVG HINIIASSMA ECEQRLNYIT GRTDIPIKIS VAQKLDLEAM 401 VKPLVGIIMG SDSDLPVMSA ACAVLKDFGV PFEVTIVSAH RTPHRMSAYA 451 ISASKRGIKT IIAGAGGAAH LPGMVAAMTP LPVIGVPVKG SCLDGVDSLH 501 SIVQMPRGVP VATVAINNST NAALLAVRLL GAYDSSYTTK MEQFLLKQEE 551 EVLVKAQKLE TVGYEAYLEN K*

Amino Acid Sequence (or in FASTA format)

       1  MDSRTVGILG GGQLGRMIVE AANRLNIKTV ILDAENSPAK QISNSNDHVN
      51  GSFSNPLDIE KLAEKCDVLT IEIEHVDVPT LKNLQVKHPK LKIYPSPETI
     101  RLIQDKYIQK EHLIKNGIAV TQSVPVEQAS ETSLLNVGRD LGFPFVLKSR
     151  TLAYDGRGNF VVKNKEMIPE ALEVLKDRPL YAEKWAPFTK ELAVMIVRSV
     201  NGLVFSYPIV ETIHKDNICD LCYAPARVPD SVQLKAKLLA ENAIKSFPGC
     251  GIFGVEMFYL ETGELLINEI APRPHNSGHY TIDACVTSQF EAHLRSILDL
     301  PMPKNFTSFS TITTNAIMLN VLGDKHTKDK ELETCERALA TPGSSVYLYG
     351  KESRPNRKVG HINIIASSMA ECEQRLNYIT GRTDIPIKIS VAQKLDLEAM
     401  VKPLVGIIMG SDSDLPVMSA ACAVLKDFGV PFEVTIVSAH RTPHRMSAYA
     451  ISASKRGIKT IIAGAGGAAH LPGMVAAMTP LPVIGVPVKG SCLDGVDSLH
     501  SIVQMPRGVP VATVAINNST NAALLAVRLL GAYDSSYTTK MEQFLLKQEE
     551  EVLVKAQKLE TVGYEAYLEN K*

external links for Ade2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Ade2p

1)	Dorfman BZ (1969) The isolation of adenylosuccinate synthetase mutants in yeast by selection for constitutive behavior in pigmented strains. Genetics 61(2):377-89
2)	Jones EW and Fink GR (1982) "Regulation of amino acid and nucleotide biosynthesis in yeast." Pp.181-299 in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41