RAS1/YOR101W Protein Information

Standard Name	Ras1p
Systematic Name	Yor101wp
ORF Classification	Verified
Description	GTPase involved in G-protein signaling in adenylate cyclase activation; plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes; relative distribution to the nucleus increases upon DNA replication stress; RAS1 has a paralog, RAS2, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description	homologous to RAS proto-oncogene

Experimental Data
Molecules/cell	2050 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	309
Molecular Weight (Da)	34,346
Isoelectric Point (pI)	5.08

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ras1p (InterPro)
Physical Interactions	There are 14 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000133121 \| P01119 MIPS: YOR101W NCBI: 1041721 \| 1164948 \| 1420281 \| 1710013 \| 172361 \| 4289 \| 6324675 \| NP_014744.1 GenBank/EMBL/DDBJ: DAA10878.1 \| K01970 \| U32307 \| X00527 \| X94335 \| Z75009

Amino Acid Sequence (or in FASTA format)
1 MQGNKSTIRE YKIVVVGGGG VGKSALTIQF IQSYFVDEYD PTIEDSYRKQ 51 VVIDDKVSIL DILDTAGQEE YSAMREQYMR TGEGFLLVYS VTSRNSFDEL 101 LSYYQQIQRV KDSDYIPVVV VGNKLDLENE RQVSYEDGLR LAKQLNAPFL 151 ETSAKQAINV DEAFYSLIRL VRDDGGKYNS MNRQLDNTNE IRDSELTSSA 201 TADREKKNNG SYVLDNSLTN AGTGSSSKSA VNHNGETTKR TDEKNYVNQN 251 NNNEGNTKYS SNGNGNRSDI SRGNQNNALN SRSKQSAEPQ KNSSANARKE 301 SSGGCCIIC*

Amino Acid Sequence (or in FASTA format)

       1  MQGNKSTIRE YKIVVVGGGG VGKSALTIQF IQSYFVDEYD PTIEDSYRKQ
      51  VVIDDKVSIL DILDTAGQEE YSAMREQYMR TGEGFLLVYS VTSRNSFDEL
     101  LSYYQQIQRV KDSDYIPVVV VGNKLDLENE RQVSYEDGLR LAKQLNAPFL
     151  ETSAKQAINV DEAFYSLIRL VRDDGGKYNS MNRQLDNTNE IRDSELTSSA
     201  TADREKKNNG SYVLDNSLTN AGTGSSSKSA VNHNGETTKR TDEKNYVNQN
     251  NNNEGNTKYS SNGNGNRSDI SRGNQNNALN SRSKQSAEPQ KNSSANARKE
     301  SSGGCCIIC*

external links for Ras1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Ras1p

1)	Fujiyama A and Tamanoi F (1986) Processing and fatty acid acylation of RAS1 and RAS2 proteins in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 83(5):1266-70
2)	Broek D, et al. (1985) Differential activation of yeast adenylate cyclase by wild-type and mutant RAS proteins. Cell 41(3):763-9
3)	Kataoka T, et al. (1984) Genetic analysis of yeast RAS1 and RAS2 genes. Cell 37(2):437-45
4)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41