KTR1/YOR099W Protein Information

Standard Name	Ktr1p
Systematic Name	Yor099wp
ORF Classification	Verified
Description	Alpha-1,2-mannosyltransferase; involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family; relocalizes from vacuole to cytoplasm upon DNA replication stress (1, 2, 3)
Name Description	Kre Two Related 1

Experimental Data
Molecules/cell	5480 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	393
Molecular Weight (Da)	46,022
Isoelectric Point (pI)	6.67

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ktr1p (InterPro)
Transmembrane Domains	There are 1 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 11 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012E11C \| P27810 MIPS: YOR099W NCBI: 1164946 \| 125725 \| 1420277 \| 3866 \| 6324673 \| NP_014742.1 GenBank/EMBL/DDBJ: DAA10876.1 \| X62941 \| X94335 \| Z75007
External Classifications	EC: 2.4.1.- [Hexosyltransferases] EC: 2.4.1.131 [GDP-Man:Man(3)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase]

Amino Acid Sequence (or in FASTA format)
1 MAKIMIPASK QPVYKKLGLL LVAVFTVYVF FHGAQYARGS APSPKYSTVL 51 SSGSGYKYSK VELPKYTGPR EKATFVTLVR NRDLYSLAES IKSVEDRFNS 101 KFNYDWVFLN DEEFTDEFKN VTSALVSGTT KYGVIPKEHW SFPEWIDEEK 151 AAQVRKEMGE KRIIYGDSIS YRHMCRFESG FFYRHPLMDD YDWYWRVEPD 201 IKLHCDIDYD VFKFMKDNKK KYAFAISIKE YEATIPTLWE TTRKFMEAHP 251 ELIHENNMLD FVSDDQGLSY NLCHFWSNFE IAALDLWRSP AYSAYFDYLD 301 REGGFFYERW GDAPVHSIGA ALFLDRSEIH HFGDIGYYHV PFHSCPIDTS 351 IRLANKCDCD PSKDFTWHSY SCTTKFYNIN KLPKPAGWQN HIG*

Amino Acid Sequence (or in FASTA format)

       1  MAKIMIPASK QPVYKKLGLL LVAVFTVYVF FHGAQYARGS APSPKYSTVL
      51  SSGSGYKYSK VELPKYTGPR EKATFVTLVR NRDLYSLAES IKSVEDRFNS
     101  KFNYDWVFLN DEEFTDEFKN VTSALVSGTT KYGVIPKEHW SFPEWIDEEK
     151  AAQVRKEMGE KRIIYGDSIS YRHMCRFESG FFYRHPLMDD YDWYWRVEPD
     201  IKLHCDIDYD VFKFMKDNKK KYAFAISIKE YEATIPTLWE TTRKFMEAHP
     251  ELIHENNMLD FVSDDQGLSY NLCHFWSNFE IAALDLWRSP AYSAYFDYLD
     301  REGGFFYERW GDAPVHSIGA ALFLDRSEIH HFGDIGYYHV PFHSCPIDTS
     351  IRLANKCDCD PSKDFTWHSY SCTTKFYNIN KLPKPAGWQN HIG*

external links for Ktr1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Ktr1p

1)	Lussier M, et al. (1997) Completion of the Saccharomyces cerevisiae genome sequence allows identification of KTR5, KTR6 and KTR7 and definition of the nine-membered KRE2/MNT1 mannosyltransferase gene family in this organism. Yeast 13(3):267-74
2)	Lussier M, et al. (1997) The Ktr1p, Ktr3p, and Kre2p/Mnt1p mannosyltransferases participate in the elaboration of yeast O- and N-linked carbohydrate chains. J Biol Chem 272(24):15527-31
3)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41