PTC5/YOR090C Protein Information Help

Standard Name Ptc5p
Systematic Name Yor090cp
Alias Ppp1p 1
ORF Classification Verified
Description Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p (1, 2, 3, 4, 5)
Name Description Phosphatase Two C 2
Experimental Data
Molecules/cell 7550 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 572
Molecular Weight (Da) 63,668
Isoelectric Point (pI) 9.22

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ptc5p (InterPro)
Physical Interactions There are 19 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006BA5E | Q12511
MIPS: YOR090C
NCBI: 1164936 | 1420259 | 55584078 | 6324664 | NP_014733.1
GenBank/EMBL/DDBJ: DAA10867.1 | X94335 | Z74998
External Classifications EC: 3.1.3.16 [Phosphoprotein phosphatase]
Amino Acid Sequence (or in FASTA format)
 
       1  MSPLTRTVAI KKTVKVLSKC QSGREYTQKF LQRAYSTSHA NSTYYSRTKL
      51  FISSHSKALN IALLSGSLLL TYSYYSPKKI LSLDTINGIK DYSTNTSGNI
     101  NMPSPNPKGT ETQKSQRSQN DQSVLILNDS KIEAKLHDRE ESHFVNRGTG
     151  IFRYDVAQLP SNHPIEDDHV EQIITIPIES EDGKSIEKDL YFFGIFDGHG
     201  GPFTSEKLSK DLVRYVAYQL GQVYDQNKTV FHSDPNQLID SAISKGFLKL
     251  DNDLVIESFR KLFQDPNNTN IANTLPAISG SCALLSLYNS TNSILKVAVT
     301  GDSRALICGL DNEGNWTVKS LSTDQTGDNL DEVRRIRKEH PGEPNVIRNG
     351  RILGSLQPSR AFGDYRYKIK EVDGKPLSDL PEVAKLYFRR EPRDFKTPPY
     401  VTAEPVITSA KIGENTKFMV MGSDGLFELL TNEEIASLVI RWMDKNMNLA
     451  PVKAEPGKLP KVIDVSEDKE AQRPAFRYKD NNSSSPSGSN PEYLIEDKNV
     501  ATHLIRNALS AGGRKEYVSA LVSIPSPMSR RYRDDLTVTV AFFGDSGTPS
     551  IVSNATSIVM NPEATTKPKP RL*

external links for Ptc5p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Ptc5p
1) Krause-Buchholz U, et al.  (2006) YIL042c and YOR090c encode the kinase and phosphatase of the Saccharomyces cerevisiae pyruvate dehydrogenase complex. FEBS Lett 580(11):2553-60
2) Cheng A, et al.  (1999) Dephosphorylation of cyclin-dependent kinases by type 2C protein phosphatases. Genes Dev 13(22):2946-57
3) Sickmann A, et al.  (2003) The proteome of Saccharomyces cerevisiae mitochondria. Proc Natl Acad Sci U S A 100(23):13207-12
4) Gey U, et al.  (2008) Yeast pyruvate dehydrogenase complex is regulated by a concerted activity of two kinases and two phosphatases. J Biol Chem 283(15):9759-67
5) Voegtle FN, et al.  (2012) Intermembrane space proteome of yeast mitochondria. Mol Cell Proteomics 11(12):1840-52
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41