SGO1/YOR073W Protein Information

Standard Name	Sgo1p 1
Systematic Name	Yor073wp
Alias	Yor29-24p
ORF Classification	Verified
Description	Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability (1, 2)
Name Description	ShuGOshin (Japanese for "guardian spirit") 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	590
Molecular Weight (Da)	66,706
Isoelectric Point (pI)	10.05

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Sgo1p (InterPro)
Physical Interactions	There are 20 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006B7E4 \| Q08490 MIPS: YOR073W NCBI: 1420227 \| 2104885 \| 6324647 \| 74583719 \| NP_014716.1 GenBank/EMBL/DDBJ: DAA10852.1 \| Z70678 \| Z74981

Amino Acid Sequence (or in FASTA format)
1 MPKRKIAPNK ESSRRTVSHD DLTPQIQEFQ NLMDLESQKV ENIRQSYSRQ 51 NSLLAKDNSI LKIKVNSLEK KISQLVQENV TLRSKTSISE AIYRERLSNQ 101 LQVIENGIIQ RFDEIFYMFE NVRKNENLPS SSLRTMLKRT SSRSRSCSLS 151 SPTYSKSYTR LSNHENNLSH ESSFNKDDGP DLEPKAKKRK SSRRQSMFVS 201 TSLEPEDETG ENEPMMENSS VEVPAESHES AQVEETIDAL NPEEENSDSV 251 SNFTNSIIEY SIPEENPTEP EHSSSKLEIF NDSTNMLSTV PSNPLPLPLP 301 GPSATLPTTT SDASTVYPSS SSSTNSHPKT KIKHSMKPPR IELKKKVIDE 351 VMPVSNMSSN SEISFTRTRR TRGKAVDYTL PSLRAKMRRP SEKLVDATTV 401 IDIHDLQVSK RNRETSHKRK SLSQDSIPDE PQLREVVVSK DYGTPKGKKT 451 EDEIHEDTAH LMTTSNNNSN NKNEKKLTSN NSPKKSSPLL DITNKSENKK 501 KSTRTKKLFK NAIVNNLSDE NSTTRPSKSS KGTSNNNNNY NNFDNNNSNI 551 NNVNNKSVSF RLNEDDLAVF DLFGNGKAVK HQPKTYRTKK *

Amino Acid Sequence (or in FASTA format)

       1  MPKRKIAPNK ESSRRTVSHD DLTPQIQEFQ NLMDLESQKV ENIRQSYSRQ
      51  NSLLAKDNSI LKIKVNSLEK KISQLVQENV TLRSKTSISE AIYRERLSNQ
     101  LQVIENGIIQ RFDEIFYMFE NVRKNENLPS SSLRTMLKRT SSRSRSCSLS
     151  SPTYSKSYTR LSNHENNLSH ESSFNKDDGP DLEPKAKKRK SSRRQSMFVS
     201  TSLEPEDETG ENEPMMENSS VEVPAESHES AQVEETIDAL NPEEENSDSV
     251  SNFTNSIIEY SIPEENPTEP EHSSSKLEIF NDSTNMLSTV PSNPLPLPLP
     301  GPSATLPTTT SDASTVYPSS SSSTNSHPKT KIKHSMKPPR IELKKKVIDE
     351  VMPVSNMSSN SEISFTRTRR TRGKAVDYTL PSLRAKMRRP SEKLVDATTV
     401  IDIHDLQVSK RNRETSHKRK SLSQDSIPDE PQLREVVVSK DYGTPKGKKT
     451  EDEIHEDTAH LMTTSNNNSN NKNEKKLTSN NSPKKSSPLL DITNKSENKK
     501  KSTRTKKLFK NAIVNNLSDE NSTTRPSKSS KGTSNNNNNY NNFDNNNSNI
     551  NNVNNKSVSF RLNEDDLAVF DLFGNGKAVK HQPKTYRTKK *

external links for Sgo1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Sgo1p

1)	Kitajima TS, et al. (2004) The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis. Nature 427(6974):510-7
2)	Indjeian VB, et al. (2005) The centromeric protein Sgo1 is required to sense lack of tension on mitotic chromosomes. Science 307(5706):130-3