RPL3/YOR063W Protein Information

Standard Name	Rpl3p
Systematic Name	Yor063wp
Alias	Mak8p , Tcm1p , Yor29-14p
ORF Classification	Verified
Description	Ribosomal 60S subunit protein L3; homologous to mammalian ribosomal protein L3 and bacterial L3; involved in the replication and maintenance of killer double stranded RNA virus (1, 2, 3, 4, 5, 6)
Name Description	Ribosomal Protein of the Large subunit
Gene Product	L3 3, 6 , YL1 3 , rp1 3

Experimental Data
Molecules/cell	450 7

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	387
Molecular Weight (Da)	43,757
Isoelectric Point (pI)	11.1

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rpl3p (InterPro)
Physical Interactions	There are 293 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000003724C \| P14126 MIPS: YOR063W NCBI: 1197059 \| 1420207 \| 2104875 \| 2507307 \| 315113303 \| 315113528 \| 315113573 \| 365767253 \| 365767294 \| 410562480 \| 49258841 \| 6324637 \| NP_014706.1 \| NM_001183482.1 GenBank/EMBL/DDBJ: DAA10842.1 \| J01351 \| Z70678 \| Z74971

Amino Acid Sequence (or in FASTA format)
1 MSHRKYEAPR HGHLGFLPRK RAASIRARVK AFPKDDRSKP VALTSFLGYK 51 AGMTTIVRDL DRPGSKFHKR EVVEAVTVVD TPPVVVVGVV GYVETPRGLR 101 SLTTVWAEHL SDEVKRRFYK NWYKSKKKAF TKYSAKYAQD GAGIERELAR 151 IKKYASVVRV LVHTQIRKTP LAQKKAHLAE IQLNGGSISE KVDWAREHFE 201 KTVAVDSVFE QNEMIDAIAV TKGHGFEGVT HRWGTKKLPR KTHRGLRKVA 251 CIGAWHPAHV MWSVARAGQR GYHSRTSINH KIYRVGKGDD EANGATSFDR 301 TKKTITPMGG FVHYGEIKND FIMVKGCIPG NRKRIVTLRK SLYTNTSRKA 351 LEEVSLKWID TASKFGKGRF QTPAEKHAFM GTLKKDL*

Amino Acid Sequence (or in FASTA format)

       1  MSHRKYEAPR HGHLGFLPRK RAASIRARVK AFPKDDRSKP VALTSFLGYK
      51  AGMTTIVRDL DRPGSKFHKR EVVEAVTVVD TPPVVVVGVV GYVETPRGLR
     101  SLTTVWAEHL SDEVKRRFYK NWYKSKKKAF TKYSAKYAQD GAGIERELAR
     151  IKKYASVVRV LVHTQIRKTP LAQKKAHLAE IQLNGGSISE KVDWAREHFE
     201  KTVAVDSVFE QNEMIDAIAV TKGHGFEGVT HRWGTKKLPR KTHRGLRKVA
     251  CIGAWHPAHV MWSVARAGQR GYHSRTSINH KIYRVGKGDD EANGATSFDR
     301  TKKTITPMGG FVHYGEIKND FIMVKGCIPG NRKRIVTLRK SLYTNTSRKA
     351  LEEVSLKWID TASKFGKGRF QTPAEKHAFM GTLKKDL*

external links for Rpl3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Rpl3p

1)	Hamil KG, et al. (1988) Constitutive transcription of yeast ribosomal protein gene TCM1 is promoted by uncommon cis- and trans-acting elements. Mol Cell Biol 8(10):4328-41
2)	Wickner RB, et al. (1982) Ribosomal protein L3 is involved in replication or maintenance of the killer double-stranded RNA genome of Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 79(15):4706-8
3)	Planta RJ and Mager WH (1998) The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae. Yeast 14(5):471-7
4)	Iouk TL, et al. (2001) Rrb1p, a yeast nuclear WD-repeat protein involved in the regulation of ribosome biosynthesis. Mol Cell Biol 21(4):1260-71
5)	Lecompte O, et al. (2002) Comparative analysis of ribosomal proteins in complete genomes: an example of reductive evolution at the domain scale. Nucleic Acids Res 30(24):5382-90
6)	Jenner L, et al. (2012) Crystal structure of the 80S yeast ribosome. Curr Opin Struct Biol 22(6):759-67
7)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41