DBP5/YOR046C Protein Information Help

Standard Name Dbp5p
Systematic Name Yor046cp
Alias Rat8p 1
ORF Classification Verified
Description Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p (2, 3, 4, 5)
Name Description Dead Box Protein
Experimental Data
Molecules/cell 14900 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 482
Molecular Weight (Da) 53,873
Isoelectric Point (pI) 7.48

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Dbp5p (InterPro)
Physical Interactions There are 40 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000128F2C | P20449
MIPS: YOR046C
NCBI: 1353268 | 1420175 | 1708152 | 2326812 | 257097239 | 261278543 | 261278544 | 326634440 | 326634442 | 326634444 | 326634448 | 333361498 | 333361501 | 6324620 | NP_014689.1
GenBank/EMBL/DDBJ: DAA10828.1 | U28135 | Z74954 | Z74955
External Classifications EC: 3.6.1.- [Hydrolases acting on acid anhydrides in phosphorous-containing anhydrides]
EC: 3.6.4.13 [RNA helicase]
Amino Acid Sequence (or in FASTA format)
 
       1  MSDTKRDPAD LLASLKIDNE KEDTSEVSTK ETVKSQPEKT ADSIKPAEKL
      51  VPKVEEKKTK QEDSNLISSE YEVKVKLADI QADPNSPLYS AKSFDELGLA
     101  PELLKGIYAM KFQKPSKIQE RALPLLLHNP PRNMIAQSQS GTGKTAAFSL
     151  TMLTRVNPED ASPQAICLAP SRELARQTLE VVQEMGKFTK ITSQLIVPDS
     201  FEKNKQINAQ VIVGTPGTVL DLMRRKLMQL QKIKIFVLDE ADNMLDQQGL
     251  GDQCIRVKRF LPKDTQLVLF SATFADAVRQ YAKKIVPNAN TLELQTNEVN
     301  VDAIKQLYMD CKNEADKFDV LTELYGLMTI GSSIIFVATK KTANVLYGKL
     351  KSEGHEVSIL HGDLQTQERD RLIDDFREGR SKVLITTNVL ARGIDIPTVS
     401  MVVNYDLPTL ANGQADPATY IHRIGRTGRF GRKGVAISFV HDKNSFNILS
     451  AIQKYFGDIE MTRVPTDDWD EVEKIVKKVL KD*

external links for Dbp5p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Dbp5p
1) Snay-Hodge CA, et al.  (1998) Dbp5p/Rat8p is a yeast nuclear pore-associated DEAD-box protein essential for RNA export. EMBO J 17(9):2663-76
2) Estruch F and Cole CN  (2003) An early function during transcription for the yeast mRNA export factor Dbp5p/Rat8p suggested by its genetic and physical interactions with transcription factor IIH components. Mol Biol Cell 14(4):1664-76
3) Tseng-Rogenski SS, et al.  (2003) Functional conservation of Dhh1p, a cytoplasmic DExD/H-box protein present in large complexes. Nucleic Acids Res 31(17):4995-5002
4) Gross T, et al.  (2007) The DEAD-box RNA helicase Dbp5 functions in translation termination. Science 315(5812):646-9
5) Noble KN, et al.  (2011) The Dbp5 cycle at the nuclear pore complex during mRNA export II: nucleotide cycling and mRNP remodeling by Dbp5 are controlled by Nup159 and Gle1. Genes Dev 25(10):1065-77
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41