CYC2/YOR037W Protein Information

Standard Name	Cyc2p
Systematic Name	Yor037wp
ORF Classification	Verified
Description	Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p) (1, 2, 3, 4)
Name Description	CYtochrome C

Experimental Data
Molecules/cell	2730 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	366
Molecular Weight (Da)	42,368
Isoelectric Point (pI)	10.42

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Cyc2p (InterPro)
Physical Interactions	There are 10 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001D47A7 \| P38909 MIPS: YOR037W NCBI: 1041662 \| 114152798 \| 1420158 \| 1706229 \| 37362694 \| 476766 \| NP_014680.2 GenBank/EMBL/DDBJ: DAA10820.1 \| L28428 \| X87331 \| Z74945
External Classifications	EC: 1.-.-.- [Oxidoreductases]

Amino Acid Sequence (or in FASTA format)
1 MLWKNYVLSS SRITRRLHKS PRKSSFSKNF FITGCLLTVG AVSSYLTYRY 51 TSERENKHEL SPSYFVKYKI SHKRDIDSSH FLLEVTPLFK QKVNIWSLMT 101 AENLWSVEIK QPEVMVVRNY TPLPLKFNPA SKEIEILKDG DNADGKLSFY 151 IKKYENGEVA RWLHHLPKGH IIEIRGPFID YEFPHLPNEL KRSRDCLYMD 201 NRNERGNNVR ENSQFIYQPY DIMMFTAGTG IVTALQLLLT ESPFRGTIKL 251 FHTDKNIKQL GPLYPILLRL QASNRVQLKI FETDRQTKQD VLKSIQKSIT 301 KPYPYKGLLP FSNVNNKNIM PVLALVCGPE SYISSISGRK YDLNQGPVGG 351 LLSKEGWNSD NVYKLS*

Amino Acid Sequence (or in FASTA format)

       1  MLWKNYVLSS SRITRRLHKS PRKSSFSKNF FITGCLLTVG AVSSYLTYRY
      51  TSERENKHEL SPSYFVKYKI SHKRDIDSSH FLLEVTPLFK QKVNIWSLMT
     101  AENLWSVEIK QPEVMVVRNY TPLPLKFNPA SKEIEILKDG DNADGKLSFY
     151  IKKYENGEVA RWLHHLPKGH IIEIRGPFID YEFPHLPNEL KRSRDCLYMD
     201  NRNERGNNVR ENSQFIYQPY DIMMFTAGTG IVTALQLLLT ESPFRGTIKL
     251  FHTDKNIKQL GPLYPILLRL QASNRVQLKI FETDRQTKQD VLKSIQKSIT
     301  KPYPYKGLLP FSNVNNKNIM PVLALVCGPE SYISSISGRK YDLNQGPVGG
     351  LLSKEGWNSD NVYKLS*

external links for Cyc2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Cyc2p

1)	Pearce DA, et al. (1998) Cyc2p is required for maintaining ionic stability and efficient cytochrome c import and mitochondrial function in Saccharomyces cerevisiae. FEBS Lett 439(3):307-11
2)	Sanchez NS, et al. (2001) Requirements of Cyc2p and the porin, Por1p, for ionic stability and mitochondrial integrity in Saccharomyces cerevisiae. Arch Biochem Biophys 392(2):326-32
3)	Bernard DG, et al. (2003) Overlapping specificities of the mitochondrial cytochrome c and c1 heme lyases. J Biol Chem 278(50):49732-42
4)	Bernard DG, et al. (2005) Cyc2p, a membrane-bound flavoprotein involved in the maturation of mitochondrial c-type cytochromes. J Biol Chem 280(48):39852-9
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41