SHE4/YOR035C Protein Information Help

Standard Name She4p 1
Systematic Name Yor035cp
Alias Dim1p 2
ORF Classification Verified
Description Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization (3, 4)
Name Description Swi5p-dependent HO Expression 1
Experimental Data
Molecules/cell 3410 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 789
Molecular Weight (Da) 89,552
Isoelectric Point (pI) 5.37

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with She4p (InterPro)
Physical Interactions There are 27 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052F3E | P51534
MIPS: YOR035C
NCBI: 1041658 | 1100797 | 1420154 | 2507127 | 313103926 | 313103927 | 6324609 | NP_014678.1
GenBank/EMBL/DDBJ: DAA10818.1 | X87331 | X93598 | Z74943
Amino Acid Sequence (or in FASTA format)
 
       1  MPLCEKGNDP IDSSTIDSLC AAFDKTLKST PDVQKYNDAI NTIFQLRQKS
      51  ESGKMPADLT NSEALKDRQK IEEILTRSYQ DHSESRVHLS KLIQNDIPFA
     101  LNLFEILSRS SIHVFVGCFS NKDATIALLN ELQIRIHYGE DTHVTYLLSI
     151  ILQLLNKFKY NFKEVRFLVK ELILRISEDE VKSMMLIIFA ELQSSFQKDF
     201  DKAVVDFMSS LIVEAEIDVG NDPLSIIVKT LSELYPSLTT LCSEIFLTKG
     251  LSKLFKKRVF EEQDLQFTKE LLRLLSSACI DETMRTYITE NYLQLLERSL
     301  NVEDVQIYSA LVLVKTWSFT KLTCINLKQL SEIFINAISR RIMPKIENVN
     351  ESAVKLEEVP KVEMSVEALA YLSLKASVKI MIRSNESFTE ILLTMIKSQK
     401  MTHCLYGLLV IMANLSTLPE ESNGSSQSIN DLKNYADLKG PGADKVGAEK
     451  ESKEDILLFN EKYILRTELI SFLKREMHNL SPNCKQQVVR VIYNITRSKN
     501  FIPQCISQGG TTIILEYLAN KQDIGEPIRI LGCRALTRML IFTNPGLIFK
     551  KYSALNAIPF LFELLPRSTP VDDNPLHNDE QIKLTDNYEA LLALTNLASS
     601  ETSDGEEVCK HIVSTKVYWS TIENLMLDEN VPLQRSTLEL ISNMMSHPLT
     651  IAAKFFNLEN PQSLRNFNIL VKLLQLSDVE SQRAVAAIFA NIATTIPLIA
     701  KELLTKKELI ENAIQVFADQ IDDIELRQRL LMLFFGLFEV IPDNGTNEVY
     751  PLLQENQKLK DALNMSLKRG DSGPEFSAAI PVILAKIKV*

external links for She4p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for She4p
1) Jansen RP, et al.  (1996) Mother cell-specific HO expression in budding yeast depends on the unconventional myosin myo4p and other cytoplasmic proteins. Cell 84(5):687-97
2) Wendland B, et al.  (1996) A novel fluorescence-activated cell sorter-based screen for yeast endocytosis mutants identifies a yeast homologue of mammalian eps15. J Cell Biol 135(6 Pt 1):1485-500
3) Toi H, et al.  (2003) She4p/Dim1p interacts with the motor domain of unconventional myosins in the budding yeast, Saccharomyces cerevisiae. Mol Biol Cell 14(6):2237-49
4) Wesche S, et al.  (2003) The UCS domain protein She4p binds to myosin motor domains and is essential for class I and class V myosin function. Curr Biol 13(9):715-24
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41