TIR2/YOR010C Protein Information

Standard Name	Tir2p
Systematic Name	Yor010cp
Alias	Srp2p
ORF Classification	Verified
Description	Putative cell wall mannoprotein; member of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis; TIR2 has a paralog, TIR3, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description	TIp1-Related 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	251
Molecular Weight (Da)	24,628
Isoelectric Point (pI)	3.88

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Tir2p (InterPro)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000036C94 \| P33890 MIPS: YOR010C NCBI: 1151006 \| 1420106 \| 388098 \| 396560 \| 464887 \| 6324584 \| NP_014653.1 GenBank/EMBL/DDBJ: DAA10793.1 \| L23521 \| U43491 \| X74428 \| Z74918

Amino Acid Sequence (or in FASTA format)
1 MAYIKIALLA AIAALASAQT QEEIDELNVI LNDVKSNLQE YISLAEDSSS 51 GFSLSSLPSG VLDIGLALAS ATDDSYTTLY SEVDFAAVSK MLTMVPWYSS 101 RLLPELESLL GTSTTAASST EASSAATSSA VASSSETTSS AVASSSEATS 151 SAVASSSEAS SSAATSSAVA SSSEATSSTV ASSTKAASST KASSSAVSSA 201 VASSTKASAI SQISDGQVQA TSTVSEQTEN GAAKAVIGMG AGVMAAAAML 251 L*

Amino Acid Sequence (or in FASTA format)

       1  MAYIKIALLA AIAALASAQT QEEIDELNVI LNDVKSNLQE YISLAEDSSS
      51  GFSLSSLPSG VLDIGLALAS ATDDSYTTLY SEVDFAAVSK MLTMVPWYSS
     101  RLLPELESLL GTSTTAASST EASSAATSSA VASSSETTSS AVASSSEATS
     151  SAVASSSEAS SSAATSSAVA SSSEATSSTV ASSTKAASST KASSSAVSSA
     201  VASSTKASAI SQISDGQVQA TSTVSEQTEN GAAKAVIGMG AGVMAAAAML
     251  L*

external links for Tir2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Tir2p

1)	Kowalski LR, et al. (1995) Cold-shock induction of a family of TIP1-related proteins associated with the membrane in Saccharomyces cerevisiae. Mol Microbiol 15(2):341-53
2)	Cohen BD, et al. (2001) Induction and repression of DAN1 and the family of anaerobic mannoprotein genes in Saccharomyces cerevisiae occurs through a complex array of regulatory sites. Nucleic Acids Res 29(3):799-808
3)	Abramova NE, et al. (2001) Regulatory mechanisms controlling expression of the DAN/TIR mannoprotein genes during anaerobic remodeling of the cell wall in Saccharomyces cerevisiae. Genetics 157(3):1169-77
4)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61