SLG1/YOR008C Protein Information

Standard Name	Slg1p
Systematic Name	Yor008cp
Alias	Hcs77p , Wsc1p
ORF Classification	Verified
Description	Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response (1, 2, 3, 4)
Name Description	Synthetic Lethal with Gap 5

Experimental Data
Molecules/cell	664 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	378
Molecular Weight (Da)	39,270
Isoelectric Point (pI)	4.52

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Slg1p (InterPro)
Transmembrane Domains	There are 1 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 9 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000135A12 \| P54867 MIPS: YOR008C NCBI: 1072110 \| 1151004 \| 1420102 \| 1711396 \| 6324581 \| NP_014650.1 GenBank/EMBL/DDBJ: DAA10790.1 \| U39481 \| U43491 \| Z74916

Amino Acid Sequence (or in FASTA format)
1 MRPNKTSLLL ALLSILSQAN AYEYVNCFSS LPSDFSKADS YNWQSSSHCN 51 SECSAKGASY FALYNHSECY CGDTNPSGSE STSSSCNTYC FGYSSEMCGG 101 EDAYSVYQLD SDTNSNSISS SDSSTESTSA SSSTTSSTTS STTSTTSSTT 151 SSTTSSMASS STVQNSPEST QAAASISTSQ SSSTVTSESS LTSDTLATSS 201 TSSQSQDATS IIYSTTFHTE GGSTIFVTNT ITASAQNSGS ATGTAGSDST 251 SGSKTHKKKA NVGAIVGGVV GGVVGAVAIA LCILLIVRHI NMKREQDRME 301 KEYQEAIKPV EYPDKLYASS FSSNHGPSSG SFEEEHTKGQ TDINPFDDSR 351 RISNGTFING GPGGKNNVLT VVNPDEAD*

Amino Acid Sequence (or in FASTA format)

       1  MRPNKTSLLL ALLSILSQAN AYEYVNCFSS LPSDFSKADS YNWQSSSHCN
      51  SECSAKGASY FALYNHSECY CGDTNPSGSE STSSSCNTYC FGYSSEMCGG
     101  EDAYSVYQLD SDTNSNSISS SDSSTESTSA SSSTTSSTTS STTSTTSSTT
     151  SSTTSSMASS STVQNSPEST QAAASISTSQ SSSTVTSESS LTSDTLATSS
     201  TSSQSQDATS IIYSTTFHTE GGSTIFVTNT ITASAQNSGS ATGTAGSDST
     251  SGSKTHKKKA NVGAIVGGVV GGVVGAVAIA LCILLIVRHI NMKREQDRME
     301  KEYQEAIKPV EYPDKLYASS FSSNHGPSSG SFEEEHTKGQ TDINPFDDSR
     351  RISNGTFING GPGGKNNVLT VVNPDEAD*

external links for Slg1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Slg1p

1)	Lodder AL, et al. (1999) Characterization of the Wsc1 protein, a putative receptor in the stress response of Saccharomyces cerevisiae. Genetics 152(4):1487-99
2)	Gualtieri T, et al. (2004) The cell wall sensor Wsc1p is involved in reorganization of actin cytoskeleton in response to hypo-osmotic shock in Saccharomyces cerevisiae. Yeast 21(13):1107-20
3)	Nanduri J and Tartakoff AM (2001) The arrest of secretion response in yeast: signaling from the secretory path to the nucleus via Wsc proteins and Pkc1p. Mol Cell 8(2):281-9
4)	Mao K, et al. (2011) Two MAPK-signaling pathways are required for mitophagy in Saccharomyces cerevisiae. J Cell Biol 193(4):755-67
5)	de Bettignies G, et al. (1999) RGD1 genetically interacts with MID2 and SLG1, encoding two putative sensors for cell integrity signalling in Saccharomyces cerevisiae. Yeast 15(16):1719-31
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41