ENB1/YOL158C Protein Information Help

Standard Name Enb1p 1
Systematic Name Yol158cp
Alias Arn4p 2
ORF Classification Verified
Description Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment (1, 3, 4, 5)
Name Description ENteroBactin 1, 2
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 606
Molecular Weight (Da) 66,969
Isoelectric Point (pI) 10.26

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Enb1p (InterPro)
Transmembrane Domains There are 11 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 2 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006C423 | Q08299
MIPS: YOL158C
NCBI: 1420070 | 51315835 | 6324415 | NP_014484.1 | NM_001183411.1
GenBank/EMBL/DDBJ: DAA10628.1 | Z74900
External Classifications TC: 2.A.1.16 [The Siderophore-Iron Transporter (SIT) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MLETDHSRND NLDDKSTVCY SEKTDSNVEK STTSGLRRID AVNKVLSDYS
      51  SFTAFGVTFS SLKTALLVAL FLQGYCTGLG GQISQSIQTY AANSFGKHSQ
     101  VGSINTVKSI VASVVAVPYA RISDRFGRIE CWIFALVLYT IGEIISAATP
     151  TFSGLFAGIV IQQFGYSGFR LLATALTGDL SGLRDRTFAM NIFLIPVIIN
     201  TWVSGNIVSS VAGNVAPYKW RWGYGIFCII VPISTLILVL PYVYAQYISW
     251  RSGKLPPLKL KEKGQTLRQT LWKFADDINL IGVILFTAFL VLVLLPLTIA
     301  GGATSKWREG HIIAMIVVGG CLGFIFLIWE LKFAKNPFIP RVYLGDPTIY
     351  VALLMEFVWR LGLQIELEYL VTVLMVAFGE STLSAQRIAQ LYNFLQSCTN
     401  IVVGIMLHFY PHPKVFVVAG SLLGVIGMGL LYKYRVVYDG ISGLIGAEIV
     451  VGIAGGMIRF PMWTLVHAST THNEMATVTG LLMSVYQIGD AVGASIAGAI
     501  WTQRLAKELI QRLGSSLGMA IYKSPLNYLK KYPIGSEVRV QMIESYSKIQ
     551  RLLIIVSISF AAFNAVLCFF LRGFTVNKKQ SLSAEEREKE KLKIKQQSWL
     601  RRVIGY*

external links for Enb1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS
YOGY CYC2008 (complexes) Pfam domains

Complexome TCDB

GeneMANIA YeastRC Structure Prediction (Seattle)

References cited on this page View Complete Literature Guide for Enb1p
1) Heymann P, et al.  (2000) A gene of the major facilitator superfamily encodes a transporter for enterobactin (Enb1p) in Saccharomyces cerevisiae. Biometals 13(1):65-72
2) Yun CW, et al.  (2000) Desferrioxamine-mediated iron uptake in Saccharomyces cerevisiae. Evidence for two pathways of iron uptake. J Biol Chem 275(14):10709-15
3) Yun CW, et al.  (2000) Siderophore-iron uptake in saccharomyces cerevisiae. Identification of ferrichrome and fusarinine transporters. J Biol Chem 275(21):16354-9
4) Emerson LR, et al.  (2002) Relationship between chloroquine toxicity and iron acquisition in Saccharomyces cerevisiae. Antimicrob Agents Chemother 46(3):787-96
5) Philpott CC, et al.  (2002) The response to iron deprivation in Saccharomyces cerevisiae: expression of siderophore-based systems of iron uptake. Biochem Soc Trans 30(4):698-702