FRE7/YOL152W Protein Information

Standard Name	Fre7p
Systematic Name	Yol152wp
ORF Classification	Verified
Description	Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels (1, 2, 3)
Name Description	Ferric REductase

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	620
Molecular Weight (Da)	70,905
Isoelectric Point (pI)	8.8

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Fre7p (InterPro)
Transmembrane Domains	There are 8 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 1 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000067CBBB \| Q12333 MIPS: YOL152W NCBI: 1420059 \| 189047111 \| 3913676 \| 84626311 \| 886945 \| NP_014489.2 GenBank/EMBL/DDBJ: DAA10634.1 \| Z48239 \| Z74894
External Classifications	EC: 1.16.1.7 [Ferric-chelate reductase] TC: 1.A.20.5

Amino Acid Sequence (or in FASTA format)
1 MIEERDLVLS NGIHCIADIH SELYARLKKE SQAATPWVYQ KQYGKFVTYF 51 VAVIIFLSLI KKLAFMYYDS SEEFLPEKKN SPTTPSVFLA RIMTKLVAFN 101 RYICYRKFPT LIFSYLGIPT SVGTFLVVMA TTLYTLLYCF VPHPFYRPCA 151 GFGSPPLSVR AGIMAISLVP FVFSLSGKIN VIGWLVGLSY EKINIYHQWA 201 SILCLFFSWV HVIPFLRQAR HEGGYERMHQ RWKASDMWRS GVPPILFLNL 251 LWLSSLPIAR RHFYEIFLQL HWILAVGFYI SLFYHVYPEL NSHMYLVATI 301 VVWFAQLFYR LAVKGYLRPG RSFMASTIAN VSIVGEGCVE LIVKDVEMAY 351 SPGQHIFVRT IDKGIISNHP FSIFPSAKYP GGIKMLIRAQ KGFSKRLYES 401 NDDMKKILID GPYGGIERDI RSFTNVYLIC SGSGISTCLP FLQKYGPILH 451 KTNLEVITLD WVVRHREDIS WIRDEMCTLS NNLRQLFLDG KIVVRIYVCS 501 DSTVPGIIKT FPQTIDTASD QSDLAKREKD TEFGQDDTES NSTFDKSNNE 551 YKGLITIIPS KPDLNQVIND YQIGFRNCFI CSGSDSLRYT VGNSVAGLQA 601 KVFSNKNVEE CYLHSESFGY *

Amino Acid Sequence (or in FASTA format)

       1  MIEERDLVLS NGIHCIADIH SELYARLKKE SQAATPWVYQ KQYGKFVTYF
      51  VAVIIFLSLI KKLAFMYYDS SEEFLPEKKN SPTTPSVFLA RIMTKLVAFN
     101  RYICYRKFPT LIFSYLGIPT SVGTFLVVMA TTLYTLLYCF VPHPFYRPCA
     151  GFGSPPLSVR AGIMAISLVP FVFSLSGKIN VIGWLVGLSY EKINIYHQWA
     201  SILCLFFSWV HVIPFLRQAR HEGGYERMHQ RWKASDMWRS GVPPILFLNL
     251  LWLSSLPIAR RHFYEIFLQL HWILAVGFYI SLFYHVYPEL NSHMYLVATI
     301  VVWFAQLFYR LAVKGYLRPG RSFMASTIAN VSIVGEGCVE LIVKDVEMAY
     351  SPGQHIFVRT IDKGIISNHP FSIFPSAKYP GGIKMLIRAQ KGFSKRLYES
     401  NDDMKKILID GPYGGIERDI RSFTNVYLIC SGSGISTCLP FLQKYGPILH
     451  KTNLEVITLD WVVRHREDIS WIRDEMCTLS NNLRQLFLDG KIVVRIYVCS
     501  DSTVPGIIKT FPQTIDTASD QSDLAKREKD TEFGQDDTES NSTFDKSNNE
     551  YKGLITIIPS KPDLNQVIND YQIGFRNCFI CSGSDSLRYT VGNSVAGLQA
     601  KVFSNKNVEE CYLHSESFGY *

external links for Fre7p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	TCDB
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Fre7p

1)	Martins LJ, et al. (1998) Metalloregulation of FRE1 and FRE2 homologs in Saccharomyces cerevisiae. J Biol Chem 273(37):23716-21
2)	Georgatsou E and Alexandraki D (1999) Regulated expression of the Saccharomyces cerevisiae Fre1p/Fre2p Fe/Cu reductase related genes. Yeast 15(7):573-84
3)	Yun CW, et al. (2001) The role of the FRE family of plasma membrane reductases in the uptake of siderophore-iron in Saccharomyces cerevisiae. J Biol Chem 276(13):10218-23