PEX11/YOL147C Protein Information

Standard Name	Pex11p 1
Systematic Name	Yol147cp
Alias	Pmp24p 2 , Pmp27p 3, 4
ORF Classification	Verified
Description	Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p (3, 5, 6, 7, 8)
Name Description	PEroXin 1

Experimental Data
Molecules/cell	1630 9

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	236
Molecular Weight (Da)	26,875
Isoelectric Point (pI)	10.65

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Pex11p (InterPro)
Physical Interactions	There are 49 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000168407 \| Q12462 MIPS: YOL147C NCBI: 1420050 \| 2498760 \| 45269910 \| 6324425 \| 683701 \| 791132 \| 886949 \| NP_014494.1 GenBank/EMBL/DDBJ: DAA10638.1 \| AY558010 \| X81465 \| Z46846 \| Z48239 \| Z74889

Amino Acid Sequence (or in FASTA format)
1 MVCDTLVYHP SVTRFVKFLD GSAGREKVLR LLQYLARFLA VQNSSLLARQ 51 LQAQFTTVRK FLRFLKPLNH LQAAAKFYDN KLASDNVVRV CNVLKNIFFA 101 AYLSLDQVNL LRILKVIPVT VLTGKKIPRW SNWCWLFGLL SGLAMDLRKI 151 QTSHAQIAAF VKAKSQSQGD EHEDHKKVLG KAYQDRYTAL RRLFWDAADS 201 FIVLNNLGYL SSNEEYVALS GVVTSILGMQ DMWKAT*

Amino Acid Sequence (or in FASTA format)

       1  MVCDTLVYHP SVTRFVKFLD GSAGREKVLR LLQYLARFLA VQNSSLLARQ
      51  LQAQFTTVRK FLRFLKPLNH LQAAAKFYDN KLASDNVVRV CNVLKNIFFA
     101  AYLSLDQVNL LRILKVIPVT VLTGKKIPRW SNWCWLFGLL SGLAMDLRKI
     151  QTSHAQIAAF VKAKSQSQGD EHEDHKKVLG KAYQDRYTAL RRLFWDAADS
     201  FIVLNNLGYL SSNEEYVALS GVVTSILGMQ DMWKAT*

external links for Pex11p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Pex11p

1)	Distel B, et al. (1996) A unified nomenclature for peroxisome biogenesis factors. J Cell Biol 135(1):1-3
2)	McCammon MT, et al. (1990) Association of glyoxylate and beta-oxidation enzymes with peroxisomes of Saccharomyces cerevisiae. J Bacteriol 172(10):5816-27
3)	Erdmann R and Blobel G (1995) Giant peroxisomes in oleic acid-induced Saccharomyces cerevisiae lacking the peroxisomal membrane protein Pmp27p. J Cell Biol 128(4):509-23
4)	Marshall PA, et al. (1995) Pmp27 promotes peroxisomal proliferation. J Cell Biol 129(2):345-55
5)	van Roermund CW, et al. (2000) Pex11p plays a primary role in medium-chain fatty acid oxidation, a process that affects peroxisome number and size in Saccharomyces cerevisiae. J Cell Biol 150(3):489-98
6)	Gurvitz A, et al. (2001) Saccharomyces cerevisiae Adr1p governs fatty acid beta-oxidation and peroxisome proliferation by regulating POX1 and PEX11. J Biol Chem 276(34):31825-30
7)	Knoblach B and Rachubinski RA (2010) Phosphorylation-dependent Activation of Peroxisome Proliferator Protein PEX11 Controls Peroxisome Abundance. J Biol Chem 285(9):6670-80
8)	Opalinski L, et al. (2011) Membrane curvature during peroxisome fission requires Pex11. EMBO J 30(1):5-16
9)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41