RTC1/YOL138C Protein Information

Standard Name	Rtc1p 1
Systematic Name	Yol138cp
Alias	Sea2p 2
ORF Classification	Verified
Description	Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif (1, 2, 3, 4)
Name Description	Restriction of Telomere Capping 1

Experimental Data
Molecules/cell	606 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	1,341
Molecular Weight (Da)	149,343
Isoelectric Point (pI)	6.93

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rtc1p (InterPro)
Physical Interactions	There are 20 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0001F7BD6C \| Q08281 MIPS: YOL138C NCBI: 1420032 \| 1628438 \| 330443723 \| 347595703 \| NP_014503.2 \| NM_001183392.2 GenBank/EMBL/DDBJ: DAA10647.2 \| X95465 \| Z74880

Amino Acid Sequence (or in FASTA format)
1 MSLSPHVENA SIPKGSTPIP KNRNVSSIGK GEFLGSSSSN NSSFRMNHYS 51 NSGQPSVLDS IRRPNLTPTF SYSNGVYMPE SHRTSSFNDS YLPYDKNPYA 101 KTTGSMSNKS NMKIKTKKNA INTNTRKSSG LIYTTKVDKE LSSIDKVNDP 151 NINGLVCAGK THLGLYKFSP SDRSIKCVHD FITPNSNTST RGTTSLLPKL 201 SKRTRQNKFS TIADVKTGFN NYKNCIAVCN NSTAISIYDL NKSSSIDNPL 251 ITSLCEHTRS INSFDFNMVE SNLIISGGQD SCVKIWDLRS NKSKSSNRSD 301 ISINTASDSI RDVKWMPGYN FASKNDQGSS TYGNLKSGYK FASIHDSGYL 351 LKFDLRQPAQ YEKKLNAHTG PGLCLNWHPN QEYIATGGRD GKCCLWFVGD 401 NANAAENTVL NYGNSPSLHA PNTSLNNSGS LAFPKLTINT GYPVTKLKFK 451 PAYSSNIYNS LLGISSMGDE AEVRIYSLAR KYIPKHVLLS ETPSLGLVWW 501 DENLIFNIDK GTRINGWDIN KEPTVLENLS KNTTTWRDLD GNGLLSVDQE 551 IGSYEVVEPE LQPTSSTTCK KHPGTIKNPK NGNPENQGII GGIKKGFSHT 601 GLTSFTPERP PTLKAGPTFS TKSLTLASGA SSFNSSSASL TSLTPQTENR 651 EEIAIEPPCI ITLDIPQIFN NIRLTKIAHS RKKNVISESS SMKNSPVEKF 701 KYLARQLKFS YIREHNVSDS ADTAYKNDIE NIDVVKNATE THGDNTTTTN 751 NNDDGDDDDD DDDDDKIIES HLLKKYNFPE NNTWATLMNE KVNNKKSKRN 801 SSSSREFDEK DVRSSISSIS ASRQSHDRAR KIDKNVEAEL QEKIQTLVDL 851 ISIATHNASV YLSIDDLTNF KIWILIRDSL LWDLKWMTSS QISSDNASNM 901 DANESSDFEA GENLKTGKEF PEEDGAGTSG AESLVEERPQ AFRANSDEPS 951 DAEKKPVSKL KEQLKNTEII PYAQPNEDSD EVLTKLKELQ NQRLESRTKM 1001 GETVSDDVII EEDEHEHQEE EQPHDSPTKS AQFHASPIAK SIPILQKREH 1051 RKSFIDTFML HSPNGYNGDT DIGNEDDNIS PRFTYNSVSP RSKVSSLQSY 1101 ATTTSQLETF KKLSSHTAPI IGSPRHAPSR PDSIGREQLS SSLTKKLAKC 1151 KKIIADPPWD TKKLIKQLYN QATETGNVVL TVNILFLFQT IYQITEIDIA 1201 KDAIAHFLLL LHRYELFGIA ADVLKYCPFE DIMGSEGDQS SIRLFCERCG 1251 ELITNESSKE KLRAEAQQTG NKKIMDKFGY WYCDSCKKKN TSCVLCERPL 1301 KKLTMVILPC GHEGHFQCIQ EWFLDENEQE CPGGCPGVAF I*

Amino Acid Sequence (or in FASTA format)

       1  MSLSPHVENA SIPKGSTPIP KNRNVSSIGK GEFLGSSSSN NSSFRMNHYS
      51  NSGQPSVLDS IRRPNLTPTF SYSNGVYMPE SHRTSSFNDS YLPYDKNPYA
     101  KTTGSMSNKS NMKIKTKKNA INTNTRKSSG LIYTTKVDKE LSSIDKVNDP
     151  NINGLVCAGK THLGLYKFSP SDRSIKCVHD FITPNSNTST RGTTSLLPKL
     201  SKRTRQNKFS TIADVKTGFN NYKNCIAVCN NSTAISIYDL NKSSSIDNPL
     251  ITSLCEHTRS INSFDFNMVE SNLIISGGQD SCVKIWDLRS NKSKSSNRSD
     301  ISINTASDSI RDVKWMPGYN FASKNDQGSS TYGNLKSGYK FASIHDSGYL
     351  LKFDLRQPAQ YEKKLNAHTG PGLCLNWHPN QEYIATGGRD GKCCLWFVGD
     401  NANAAENTVL NYGNSPSLHA PNTSLNNSGS LAFPKLTINT GYPVTKLKFK
     451  PAYSSNIYNS LLGISSMGDE AEVRIYSLAR KYIPKHVLLS ETPSLGLVWW
     501  DENLIFNIDK GTRINGWDIN KEPTVLENLS KNTTTWRDLD GNGLLSVDQE
     551  IGSYEVVEPE LQPTSSTTCK KHPGTIKNPK NGNPENQGII GGIKKGFSHT
     601  GLTSFTPERP PTLKAGPTFS TKSLTLASGA SSFNSSSASL TSLTPQTENR
     651  EEIAIEPPCI ITLDIPQIFN NIRLTKIAHS RKKNVISESS SMKNSPVEKF
     701  KYLARQLKFS YIREHNVSDS ADTAYKNDIE NIDVVKNATE THGDNTTTTN
     751  NNDDGDDDDD DDDDDKIIES HLLKKYNFPE NNTWATLMNE KVNNKKSKRN
     801  SSSSREFDEK DVRSSISSIS ASRQSHDRAR KIDKNVEAEL QEKIQTLVDL
     851  ISIATHNASV YLSIDDLTNF KIWILIRDSL LWDLKWMTSS QISSDNASNM
     901  DANESSDFEA GENLKTGKEF PEEDGAGTSG AESLVEERPQ AFRANSDEPS
     951  DAEKKPVSKL KEQLKNTEII PYAQPNEDSD EVLTKLKELQ NQRLESRTKM
    1001  GETVSDDVII EEDEHEHQEE EQPHDSPTKS AQFHASPIAK SIPILQKREH
    1051  RKSFIDTFML HSPNGYNGDT DIGNEDDNIS PRFTYNSVSP RSKVSSLQSY
    1101  ATTTSQLETF KKLSSHTAPI IGSPRHAPSR PDSIGREQLS SSLTKKLAKC
    1151  KKIIADPPWD TKKLIKQLYN QATETGNVVL TVNILFLFQT IYQITEIDIA
    1201  KDAIAHFLLL LHRYELFGIA ADVLKYCPFE DIMGSEGDQS SIRLFCERCG
    1251  ELITNESSKE KLRAEAQQTG NKKIMDKFGY WYCDSCKKKN TSCVLCERPL
    1301  KKLTMVILPC GHEGHFQCIQ EWFLDENEQE CPGGCPGVAF I*

external links for Rtc1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Rtc1p

1)	Addinall SG, et al. (2008) A Genomewide Suppressor and Enhancer Analysis of cdc13-1 Reveals Varied Cellular Processes Influencing Telomere Capping in Saccharomyces cerevisiae. Genetics 180(4):2251-66
2)	Dokudovskaya S, et al. (2011) A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol Cell Proteomics 10(6):M110.006478
3)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
4)	Fleischer TC, et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41