TRM11/YOL124C Protein Information

Standard Name	Trm11p 1
Systematic Name	Yol124cp
ORF Classification	Verified
Description	Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain (1)
Name Description	TRna Methyltransferase 1

Experimental Data
Molecules/cell	2020 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	433
Molecular Weight (Da)	50,072
Isoelectric Point (pI)	7.97

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Trm11p (InterPro)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 8 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052EED \| Q12463 MIPS: YOL124C NCBI: 1209718 \| 1420005 \| 6324448 \| 74655048 \| NP_014517.1 GenBank/EMBL/DDBJ: DAA10660.1 \| U41293 \| Z74866
External Classifications	EC: 2.1.1.- [Transferases transferring one-carbon groups methyltransferases]

Amino Acid Sequence (or in FASTA format)
1 MKKYLLYMVQ VHLNFRRAEL ESLADLYNLS IDFSQYDANS PFFIVELEND 51 QQAKDWIKRS ILTRGIYEYW GQGTTLDELH KDIQRQSNFE QDLQLKFKHS 101 TFKFEFECYK GNSKAKRVEQ IETFRYLGFE GKIDMKHPQE VFTVIEEYTP 151 ISENVGGKTP TRIYFGRQVQ MSNRSAMEKY DLKKRPYKGT TSFEAELSLV 201 SANIAQVKPG TIMYDPFAGT GSFLVAGGHF GSLVIGSDID GRMIRGKGAQ 251 VNISANFKKY GESSQFLDVL TMDFTNNALR NNLVIDTILC DPPYGIRESI 301 KVLGAKDPER FLGKEDMEID GEKAYLRRDY IPTKKPYALD SLLDDLLQYS 351 SERLPIGGRL AFWMPTANDA NIETIVPMHE NLELKYNCVQ EFNKWSRRLL 401 VYINRGSTFN GSSNHGIKRS KDNFRERYFN NFN*

Amino Acid Sequence (or in FASTA format)

       1  MKKYLLYMVQ VHLNFRRAEL ESLADLYNLS IDFSQYDANS PFFIVELEND
      51  QQAKDWIKRS ILTRGIYEYW GQGTTLDELH KDIQRQSNFE QDLQLKFKHS
     101  TFKFEFECYK GNSKAKRVEQ IETFRYLGFE GKIDMKHPQE VFTVIEEYTP
     151  ISENVGGKTP TRIYFGRQVQ MSNRSAMEKY DLKKRPYKGT TSFEAELSLV
     201  SANIAQVKPG TIMYDPFAGT GSFLVAGGHF GSLVIGSDID GRMIRGKGAQ
     251  VNISANFKKY GESSQFLDVL TMDFTNNALR NNLVIDTILC DPPYGIRESI
     301  KVLGAKDPER FLGKEDMEID GEKAYLRRDY IPTKKPYALD SLLDDLLQYS
     351  SERLPIGGRL AFWMPTANDA NIETIVPMHE NLELKYNCVQ EFNKWSRRLL
     401  VYINRGSTFN GSSNHGIKRS KDNFRERYFN NFN*

external links for Trm11p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Trm11p

1)	Purushothaman SK, et al. (2005) Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA. Mol Cell Biol 25(11):4359-70
2)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41