MDY2/YOL111C Protein Information

Standard Name	Mdy2p 1
Systematic Name	Yol111cp
Alias	Tma24p 2 , Get5p 3
ORF Classification	Verified
Description	Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes (1, 2, 3, 4)
Name Description	Mating-Deficient Yeast 1, 2

Experimental Data
Molecules/cell	6510 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	212
Molecular Weight (Da)	23,732
Isoelectric Point (pI)	10.01

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mdy2p (InterPro)
Physical Interactions	There are 62 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006B109 \| Q12285 MIPS: YOL111C NCBI: 1419979 \| 284793802 \| 284793803 \| 284793804 \| 284793805 \| 299689115 \| 299689117 \| 299689119 \| 374073963 \| 374073964 \| 374074609 \| 374074610 \| 414145392 \| 422919060 \| 422919063 \| 422920049 \| 422920050 \| 422920051 \| 442570517 \| 6324461 \| 663243 \| 74676570 \| NP_014530.1 GenBank/EMBL/DDBJ: DAA10672.1 \| Z48149 \| Z74853

Amino Acid Sequence (or in FASTA format)
1 MSTSASGPEH EFVSKFLTLA TLTEPKLPKS YTKPLKDVTN LGVPLPTLKY 51 KYKQNRAKKL KLHQDQQGQD NAAVHLTLKK IQAPKFSIEH DFSPSDTILQ 101 IKQHLISEEK ASHISEIKLL LKGKVLHDNL FLSDLKVTPA NSTITVMIKP 151 NPTISKEPEA EKSTNSPAPA PPQELTVPWD DIEALLKNNF ENDQAAVRQV 201 MERLQKGWSL AK*

Amino Acid Sequence (or in FASTA format)

       1  MSTSASGPEH EFVSKFLTLA TLTEPKLPKS YTKPLKDVTN LGVPLPTLKY
      51  KYKQNRAKKL KLHQDQQGQD NAAVHLTLKK IQAPKFSIEH DFSPSDTILQ
     101  IKQHLISEEK ASHISEIKLL LKGKVLHDNL FLSDLKVTPA NSTITVMIKP
     151  NPTISKEPEA EKSTNSPAPA PPQELTVPWD DIEALLKNNF ENDQAAVRQV
     201  MERLQKGWSL AK*

external links for Mdy2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Mdy2p

1)	Hu Z, et al. (2006) Mdy2, a ubiquitin-like (UBL)-domain protein, is required for efficient mating in Saccharomyces cerevisiae. J Cell Sci 119(Pt 2):326-38
2)	Fleischer TC, et al. (2006) Systematic identification and functional screens of uncharacterized proteins associated with eukaryotic ribosomal complexes. Genes Dev 20(10):1294-307
3)	Jonikas MC, et al. (2009) Comprehensive characterization of genes required for protein folding in the endoplasmic reticulum. Science 323(5922):1693-7
4)	Chang YW, et al. (2010) Crystal structure of Get4-Get5 complex and its interactions with Sgt2, Get3, and Ydj1. J Biol Chem 285(13):9962-70
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41