INO4/YOL108C Protein Information Help

Standard Name Ino4p
Systematic Name Yol108cp
ORF Classification Verified
Description Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain (1, 2)
Name Description INOsitol requiring
Experimental Data
Molecules/cell 521 3
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 151
Molecular Weight (Da) 17,378
Isoelectric Point (pI) 10.21

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Ino4p (InterPro)
Physical Interactions There are 41 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052FE6 | P13902
MIPS: YOL108C
NCBI: 124504 | 1419973 | 171756 | 51013777 | 6324464 | 663245 | NP_014533.1 | NM_001183362.1
GenBank/EMBL/DDBJ: DAA10675.1 | AY693163 | J05267 | Z48149 | Z74850
Amino Acid Sequence (or in FASTA format)
 
       1  MTNDIKEIQT IQPGLSEIKE IKGELANVKK RKRRSKKINK LTDGQIRINH
      51  VSSEKKRREL ERAIFDELVA VVPDLQPQES RSELIIYLKS LSYLSWLYER
     101  NEKLRKQIIA KHEAKTGSSS SSDPVQEQNG NIRDLVPKEL IWELGDGQSG
     151  Q*

external links for Ino4p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Ino4p
1) Schwank S, et al.  (1995) Yeast transcriptional activator INO2 interacts as an Ino2p/Ino4p basic helix-loop-helix heteromeric complex with the inositol/choline-responsive element necessary for expression of phospholipid biosynthetic genes in Saccharomyces cerevisiae. Nucleic Acids Res 23(2):230-7
2) Santiago TC and Mamoun CB  (2003) Genome expression analysis in yeast reveals novel transcriptional regulation by inositol and choline and new regulatory functions for Opi1p, Ino2p, and Ino4p. J Biol Chem 278(40):38723-30
3) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41