WSC3/YOL105C Protein Information Help

Standard Name Wsc3p
Systematic Name Yol105cp
ORF Classification Verified
Description Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity; involved in response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis; WSC3 has a paralog, WSC2, that arose from the whole genome duplication (1, 2, 3, 4, 5)
Name Description cell Wall integrity and Stress response Component 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 556
Molecular Weight (Da) 58,229
Isoelectric Point (pI) 5.99

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Wsc3p (InterPro)
Transmembrane Domains There are 2 total predicted transmembrane domains (TMHMM)
Signal Peptide(s) There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions There are 12 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000138F9F | Q12215
MIPS: YOL105C
NCBI: 1419967 | 26401288 | 62467557 | 6324467 | 663247 | NP_014536.1
GenBank/EMBL/DDBJ: DAA10677.1 | AY899243 | Z48149 | Z74847
Amino Acid Sequence (or in FASTA format)
 
       1  MERVWFAKLT NKGTIKIGYI SFILLSLLCQ SLIGLVNADF NYEGCYSAAD
      51  IQSAGLSLKN SYIYQSVSYC QNQCPESAVV ALFNGSDCYC GNSVSFLTSL
     101  TKSTDSNCGT KCSGWPYQMC GGSSYMNVYV NAETFVSSVE SSSSKEGSST
     151  SYMPSTTSSL SSAQISSTTR RTSTDMKSSE MIATTVSTTS TTSSSTSSTT
     201  SSTTSSTTSS TTSSTTSSST SSTTSSTTSS TTSSTTSSTT SSTTSSTTSS
     251  TTSSTTSIFS VTSSSSSITL SSSEHTTVDS RTSSPSSTLV PVSSSSSTLS
     301  TPKVTSMTPS TSSTIPIVTS VELVTSVVTK AIVSTSDQHQ ETIFVTRTSV
     351  VERSSEVATA TAAASNNRSN STSKQRLSGG AIAGIVIGVV FGVIFIILIL
     401  LFLIWRRRKS HDQLDLEETK HYQPYSFGDE DANPIGPPPS SGTTNWMRHS
     451  RGNTAGSIGT SNMYGFSMSN GANYSSPSSN TSGSIINNLA GLQDATVQKQ
     501  NLPSTVFEEA NTLNSANERF SANSLPDMMM SGPLQVVNPD NPDNPELSST
     551  VSHNRA*

external links for Wsc3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Wsc3p
1) Verna J, et al.  (1997) A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 94(25):13804-9
2) Zu T, et al.  (2001) Mutations in WSC genes for putative stress receptors result in sensitivity to multiple stress conditions and impairment of Rlm1-dependent gene expression in Saccharomyces cerevisiae. Mol Genet Genomics 266(1):142-55
3) Sekiya-Kawasaki M, et al.  (2002) Dissection of upstream regulatory components of the Rho1p effector, 1,3-beta-glucan synthase, in Saccharomyces cerevisiae. Genetics 162(2):663-76
4) Wojda I, et al.  (2003) Response to high osmotic conditions and elevated temperature in Saccharomyces cerevisiae is controlled by intracellular glycerol and involves coordinate activity of MAP kinase pathways. Microbiology 149(Pt 5):1193-204
5) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61