ITR2/YOL103W Protein Information

Standard Name	Itr2p
Systematic Name	Yol103wp
Alias	Hrb612p
ORF Classification	Verified
Description	Myo-inositol transporter; member of the sugar transporter superfamily; expressed constitutively; ITR2 has a paralog, ITR1, that arose from the whole genome duplication (1, 2, 3)
Name Description	myo-Inositol TRansporter 1

Experimental Data
Molecules/cell	468 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	609
Molecular Weight (Da)	66,710
Isoelectric Point (pI)	8.25

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Itr2p (InterPro)
Transmembrane Domains	There are 12 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 2 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001D47A4 \| P30606 MIPS: YOL103W NCBI: 115502408 \| 1419961 \| 218439 \| 266396 \| 37362691 \| 663251 \| NP_014538.2 GenBank/EMBL/DDBJ: DAA10681.1 \| D90353 \| Z48149 \| Z74845
External Classifications	TC: 2.A.1.1 [The Sugar Porter (SP) Family]

Amino Acid Sequence (or in FASTA format)
1 MKNSTAASSR WTKSRLSHFF PSYTNSSGMG AASTDQSSTQ GEELHHRKHC 51 EEDNDGQKPK KSPVSTSTMQ IKSRQDEDED DGRIVIKPVN DEDDTSVIIT 101 FNQSISPFII TLTFVASISG FMFGYDTGYI SSALISINRD LDNKVLTYGE 151 KELITAATSL GALITSVGAG TAADVFGRRP CLMFSNLMFL IGAILQITAH 201 KFWQMAAGRL IMGFGVGIGS LISPLFISEI APKMIRGRLT VINSLWLTGG 251 QLIAYGCGAG LNHVKNGWRI LVGLSLIPTV LQFSFFCFLP DTPRYYVMKG 301 DLKRAKMVLK RSYVNTEDEI IDQKVEELSS LNQSIPGKNP ITKFWNMVKE 351 LHTVPSNFRA LIIGCGLQAI QQFTGWNSLM YFSGTIFETV GFKNSSAVSI 401 IVSGTNFVFT LIAFFCIDKI GRRYILLIGL PGMTVALVIC AIAFHFLGIK 451 FNGADAVVAS DGFSSWGIVI IVFIIVYAAF YALGIGTVPW QQSELFPQNV 501 RGVGTSYATA TNWAGSLVIA STFLTMLQNI TPTGTFSFFA GVACLSTIFC 551 YFCYPELSGL ELEEVQTILK DGFNIKASKA LAKKRKQQVA EGAAHHKLKF 601 EPTQEIVES*

Amino Acid Sequence (or in FASTA format)

       1  MKNSTAASSR WTKSRLSHFF PSYTNSSGMG AASTDQSSTQ GEELHHRKHC
      51  EEDNDGQKPK KSPVSTSTMQ IKSRQDEDED DGRIVIKPVN DEDDTSVIIT
     101  FNQSISPFII TLTFVASISG FMFGYDTGYI SSALISINRD LDNKVLTYGE
     151  KELITAATSL GALITSVGAG TAADVFGRRP CLMFSNLMFL IGAILQITAH
     201  KFWQMAAGRL IMGFGVGIGS LISPLFISEI APKMIRGRLT VINSLWLTGG
     251  QLIAYGCGAG LNHVKNGWRI LVGLSLIPTV LQFSFFCFLP DTPRYYVMKG
     301  DLKRAKMVLK RSYVNTEDEI IDQKVEELSS LNQSIPGKNP ITKFWNMVKE
     351  LHTVPSNFRA LIIGCGLQAI QQFTGWNSLM YFSGTIFETV GFKNSSAVSI
     401  IVSGTNFVFT LIAFFCIDKI GRRYILLIGL PGMTVALVIC AIAFHFLGIK
     451  FNGADAVVAS DGFSSWGIVI IVFIIVYAAF YALGIGTVPW QQSELFPQNV
     501  RGVGTSYATA TNWAGSLVIA STFLTMLQNI TPTGTFSFFA GVACLSTIFC
     551  YFCYPELSGL ELEEVQTILK DGFNIKASKA LAKKRKQQVA EGAAHHKLKF
     601  EPTQEIVES*

external links for Itr2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	TCDB
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Itr2p

1)	Nikawa J, et al. (1991) Isolation and characterization of two distinct myo-inositol transporter genes of Saccharomyces cerevisiae. J Biol Chem 266(17):11184-91
2)	Nikawa J, et al. (1993) Differential regulation of two myo-inositol transporter genes of Saccharomyces cerevisiae. Mol Microbiol 10(5):955-61
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41