COQ3/YOL096C Protein Information

Standard Name	Coq3p
Systematic Name	Yol096cp
ORF Classification	Verified
Description	O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein (1, 2, 3)
Name Description	COenzyme Q

Experimental Data
Molecules/cell	259 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	312
Molecular Weight (Da)	36,331
Isoelectric Point (pI)	6.95

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Coq3p (InterPro)
Physical Interactions	There are 8 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001D47A5 \| P27680 MIPS: YOL096C NCBI: 116930 \| 1419946 \| 171392 \| 2315263 \| 37362692 \| 663257 \| 92090588 \| NP_014545.2 GenBank/EMBL/DDBJ: DAA10688.1 \| M73270 \| Z48149 \| Z74837 \| Z74838
External Classifications	EC: 2.1.1.- [Transferases transferring one-carbon groups methyltransferases] EC: 2.1.1.114 [Polyprenyldihydroxybenzoate methyltransferase] EC: 2.1.1.222 [2-polyprenyl-6-hydroxyphenyl methylase] EC: 2.1.1.64 [3-demethylubiquinol 3-O-methyltransferase]

Amino Acid Sequence (or in FASTA format)
1 MLLRSRFLKV IHVRKQLSAC SRFAIQTQTR CKSTDASEDE VKHFQELAPT 51 WWDTDGSQRI LHKMNLTRLD FVQRTVRNQV KIQNPEIFVP GFNYKEFLPE 101 YVCDNIQREM QESIETNLDK RPEVSVLDVG CGGGILSESL ARLKWVKNVQ 151 GIDLTRDCIM VAKEHAKKDP MLEGKINYEC KALEDVTGQF DIITCMEMLE 201 HVDMPSEILR HCWSRLNPEK GILFLSTINR DLISWFTTIF MGENVLKIVP 251 KGTHHLSKYI NSKEILAWFN DNYSGQFRLL DLKGTMYLPY QGWVEHDCSD 301 VGNYFMAIQR LN*

Amino Acid Sequence (or in FASTA format)

       1  MLLRSRFLKV IHVRKQLSAC SRFAIQTQTR CKSTDASEDE VKHFQELAPT
      51  WWDTDGSQRI LHKMNLTRLD FVQRTVRNQV KIQNPEIFVP GFNYKEFLPE
     101  YVCDNIQREM QESIETNLDK RPEVSVLDVG CGGGILSESL ARLKWVKNVQ
     151  GIDLTRDCIM VAKEHAKKDP MLEGKINYEC KALEDVTGQF DIITCMEMLE
     201  HVDMPSEILR HCWSRLNPEK GILFLSTINR DLISWFTTIF MGENVLKIVP
     251  KGTHHLSKYI NSKEILAWFN DNYSGQFRLL DLKGTMYLPY QGWVEHDCSD
     301  VGNYFMAIQR LN*

external links for Coq3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	GeneMANIA
YOGY

References cited on this page View Complete Literature Guide for Coq3p

1)	Poon WW, et al. (1999) Yeast and rat Coq3 and Escherichia coli UbiG polypeptides catalyze both O-methyltransferase steps in coenzyme Q biosynthesis. J Biol Chem 274(31):21665-72
2)	Marbois B, et al. (2005) Coq3 and Coq4 define a polypeptide complex in yeast mitochondria for the biosynthesis of coenzyme Q. J Biol Chem 280(21):20231-8
3)	Tauche A, et al. (2008) Ubiquinone biosynthesis in Saccharomyces cerevisiae: the molecular organization of O-methylase Coq3p depends on Abc1p/Coq8p. FEMS Yeast Res 8(8):1263-75
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41