YPQ1/YOL092W Protein Information

Standard Name	Ypq1p 1
Systematic Name	Yol092wp
ORF Classification	Verified
Description	Putative vacuolar membrane transporter for cationic amino acids; likely contributes to amino acid homeostasis by exporting cationic amino acids from the vacuole; member of the PQ-loop family, with seven transmembrane domains; similar to mammalian PQLC2 vacuolar transporter; YPQ1 has a paralog, RTC2, that arose from the whole genome duplication (1, 2)
Name Description	Yeast PQ-loop protein 1

Experimental Data
Molecules/cell	1800 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	308
Molecular Weight (Da)	34,872
Isoelectric Point (pI)	4.61

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ypq1p (InterPro)
Transmembrane Domains	There are 7 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 2 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006C18D \| Q12010 MIPS: YOL092W NCBI: 1419938 \| 600466 \| 6324480 \| 74676498 \| NP_014549.1 GenBank/EMBL/DDBJ: DAA10692.1 \| X83121 \| Z74834

Amino Acid Sequence (or in FASTA format)
1 MQLVPLELNR STLSGISGSI SISCWIIVFV PQIYENFYRK SSDGLSLLFV 51 VLWLAGDVFN LMGAVMQHLL STMIILAAYY TVADIILLGQ CLWYDNEEKP 101 AVDPIHLSPA NPINENVLHD VFNEQQPLLN SQGQPNRIDE EMAAPSSDGN 151 AGDDNLREVN SRNLIKDIFI VSGVVFVGFI SWYVTYCVNY TQPPPVEDPS 201 LPVPELQINW MAQIFGYLSA LLYLGSRIPQ ILLNFKRKSC EGISFLFFLF 251 ACLGNTTFIF SVIVISLDWK YLIMNASWLV GSIGTLFMDF VIFSQFFIYK 301 RNKKFILN*

Amino Acid Sequence (or in FASTA format)

       1  MQLVPLELNR STLSGISGSI SISCWIIVFV PQIYENFYRK SSDGLSLLFV
      51  VLWLAGDVFN LMGAVMQHLL STMIILAAYY TVADIILLGQ CLWYDNEEKP
     101  AVDPIHLSPA NPINENVLHD VFNEQQPLLN SQGQPNRIDE EMAAPSSDGN
     151  AGDDNLREVN SRNLIKDIFI VSGVVFVGFI SWYVTYCVNY TQPPPVEDPS
     201  LPVPELQINW MAQIFGYLSA LLYLGSRIPQ ILLNFKRKSC EGISFLFFLF
     251  ACLGNTTFIF SVIVISLDWK YLIMNASWLV GSIGTLFMDF VIFSQFFIYK
     301  RNKKFILN*

external links for Ypq1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	GeneMANIA
YOGY

References cited on this page View Complete Literature Guide for Ypq1p

1)	Jezegou A, et al. (2012) Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy. Proc Natl Acad Sci U S A 109(50):E3434-43
2)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41