MPD2/YOL088C Protein Information

Standard Name	Mpd2p
Systematic Name	Yol088cp
ORF Classification	Verified
Description	Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p (1, 2, 3)

Experimental Data
Molecules/cell	1520 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	277
Molecular Weight (Da)	32,401
Isoelectric Point (pI)	6.51

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mpd2p (InterPro)
Transmembrane Domains	There are 1 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 33 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000006AA3B \| Q99316 MIPS: YOL088C NCBI: 1419930 \| 2424970 \| 50401138 \| 600470 \| 6324484 \| NP_014553.1 GenBank/EMBL/DDBJ: DAA10696.1 \| D34634 \| X83121 \| Z74830
External Classifications	EC: 5.3.4.1 [Protein disulfide-isomerase]

Amino Acid Sequence (or in FASTA format)
1 MKLHGFLFSV LSTCVVILPA LAYSEAVTMV KSIEQYFDIC NRNDSYTMIK 51 YYTSWCQHCK TLAPVYEELG ELYAKKANKD DTPINFLEVN CEFFGPTLCT 101 DLPGFPIIEL VKPRTKPLVL PKLDWSSMKF HERLWQRIKT WFNNPKYQLD 151 TSRVVRFEGS RNLKSLSNFI DTVRSKDTEE RFIEHIFDDS RNCNEELRSQ 201 QLLCKAGKEY YSDTLSKLYG DVNGLEKERR RLEALIKQNG DDLSKEVKEK 251 LKIIRLQLSL LSHIEDQLED TSSHDEL*

Amino Acid Sequence (or in FASTA format)

       1  MKLHGFLFSV LSTCVVILPA LAYSEAVTMV KSIEQYFDIC NRNDSYTMIK
      51  YYTSWCQHCK TLAPVYEELG ELYAKKANKD DTPINFLEVN CEFFGPTLCT
     101  DLPGFPIIEL VKPRTKPLVL PKLDWSSMKF HERLWQRIKT WFNNPKYQLD
     151  TSRVVRFEGS RNLKSLSNFI DTVRSKDTEE RFIEHIFDDS RNCNEELRSQ
     201  QLLCKAGKEY YSDTLSKLYG DVNGLEKERR RLEALIKQNG DDLSKEVKEK
     251  LKIIRLQLSL LSHIEDQLED TSSHDEL*

external links for Mpd2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Mpd2p

1)	Frand AR and Kaiser CA (1999) Ero1p oxidizes protein disulfide isomerase in a pathway for disulfide bond formation in the endoplasmic reticulum. Mol Cell 4(4):469-77
2)	Tachikawa H, et al. (1997) Overproduction of Mpd2p suppresses the lethality of protein disulfide isomerase depletion in a CXXC sequence dependent manner. Biochem Biophys Res Commun 239(3):710-4
3)	Kimura T, et al. (2004) Functional differences between human and yeast protein disulfide isomerase family proteins. Biochem Biophys Res Commun 320(2):359-65
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41