MPD2/YOL088C Protein Information Help

Standard Name Mpd2p
Systematic Name Yol088cp
ORF Classification Verified
Description Member of the protein disulfide isomerase (PDI) family; exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p (1, 2, 3)
Experimental Data
Molecules/cell 1520 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 277
Molecular Weight (Da) 32,401
Isoelectric Point (pI) 6.51

Click on image for expanded interactive view
pbrowse

Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Mpd2p (InterPro)
Transmembrane Domains There are 1 total predicted transmembrane domains (TMHMM)
Signal Peptide(s) There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions There are 34 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000006AA3B | Q99316
MIPS: YOL088C
NCBI: 1419930 | 2424970 | 50401138 | 600470 | 6324484 | NP_014553.1 | NM_001183342.1
GenBank/EMBL/DDBJ: BAA22222.1 | CAA58191.1 | CAA99100.1 | DAA10696.1 | D34634 | X83121 | Z74830
External Classifications EC: 5.3.4.1 [Protein disulfide-isomerase]
Amino Acid Sequence (or in FASTA format)
       1  MKLHGFLFSV LSTCVVILPA LAYSEAVTMV KSIEQYFDIC NRNDSYTMIK
      51  YYTSWCQHCK TLAPVYEELG ELYAKKANKD DTPINFLEVN CEFFGPTLCT
     101  DLPGFPIIEL VKPRTKPLVL PKLDWSSMKF HERLWQRIKT WFNNPKYQLD
     151  TSRVVRFEGS RNLKSLSNFI DTVRSKDTEE RFIEHIFDDS RNCNEELRSQ
     201  QLLCKAGKEY YSDTLSKLYG DVNGLEKERR RLEALIKQNG DDLSKEVKEK
     251  LKIIRLQLSL LSHIEDQLED TSSHDEL*                        

external links for Mpd2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB CYC2008 (complexes) MIPS YeastGFP
YOGY Complexome Pfam domains YeastRC Public Image Repository

DIP YeastRC Structure Prediction (Seattle)

GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Mpd2p
1) Frand AR and Kaiser CA  (1999) Ero1p oxidizes protein disulfide isomerase in a pathway for disulfide bond formation in the endoplasmic reticulum. Mol Cell 4(4):469-77
2) Tachikawa H, et al.  (1997) Overproduction of Mpd2p suppresses the lethality of protein disulfide isomerase depletion in a CXXC sequence dependent manner. Biochem Biophys Res Commun 239(3):710-4
3) Kimura T, et al.  (2004) Functional differences between human and yeast protein disulfide isomerase family proteins. Biochem Biophys Res Commun 320(2):359-65
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41