MDM20/YOL076W Protein Information Help

Standard Name Mdm20p
Systematic Name Yol076wp
Alias Dec1p , Naa25p 1
ORF Classification Verified
Description Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly (2, 3)
Name Description Mitochondrial Distribution and Morphology
Experimental Data
Molecules/cell 5800 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 796
Molecular Weight (Da) 92,808
Isoelectric Point (pI) 7.7

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Mdm20p (InterPro)
Physical Interactions There are 12 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001290EA | Q12387
MIPS: YOL076W
NCBI: 1033068 | 1322287 | 1419907 | 2498298 | 51013611 | 6324497 | NP_014566.1
GenBank/EMBL/DDBJ: DAA10708.1 | AY693080 | U36382 | U54799 | Z74818
Amino Acid Sequence (or in FASTA format)
 
       1  MSDKIQEEIL GLVSRSNFKQ CYAKLGQLQK QFPNALYFKI LETYVKFKQS
      51  PGKFDYNKLL EEPYGLKGTT ITGDTRSLEF LHNFFVELGK YDEALHVYER
     101  GNFKFPSYEL SYHWFMKALE DSNYNQMSKA SLQLAKYSDS GNLPKRAYYF
     151  WNAISILAVS RFQENTLSDP KKILLSRLAR QSLLDLKPFQ NVQEIIVYCL
     201  VLDELFPQSR EISEEIVAIT FANFDTSVNL YLKNFILKHT KLLNSPQKLF
     251  EVCSKLIEKG LDDYELITNL IDAAYKLSKS KDEVKQWIDE NLGDSRNTRL
     301  ARLKLDIMYT DSVSESSLSY YLSKYHNKPC CSIDLNHYSG HINIDMLKSI
     351  MSKYDPEDKD LIHHCNILEL GLIGSDSINN YNKFKGTLEK KSVTDYSSCS
     401  TFLLEIVKDK CKKTNPELKD VLLCITILEN YQAKDPHNFD TMCWLIVLYM
     451  YLGLVPDAYF HFINLKIKNV QTDSLDYMIF SRFSTLFPNK QSDFYSKTFH
     501  EHNNLYDTSL ANLPRYIQVA FERNSYSKIL GMLEMRDKLM KSYTRWTKTL
     551  ENLQFSRLCN DKRGHLLQKL HEDWRSLEMT QSVSFSDNRD FSILDENFAQ
     601  FLNRGKILEY ANLNEESIFL TLIRELIIEA LPNGEKTEQI SALLKKLPSI
     651  NLEELLNNNL TEVESASFLI FFEIYENNGK NLHDLISRLM KVPINAKQNW
     701  MVSHTYLTKM ATLKTLDSLK RIKDKEIQKL IKNSLKELRS CCDDVFKGYS
     751  KALVQAYEEL KKDECGNLLK ELDVKAENVK NIKNSLLGIQ KSVRNL*

external links for Mdm20p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Mdm20p
1) Polevoda B, et al.  (2009) A synopsis of eukaryotic Nalpha-terminal acetyltransferases: nomenclature, subunits and substrates. BMC Proc 3 Suppl 6:S2
2) Singer JM and Shaw JM  (2003) Mdm20 protein functions with Nat3 protein to acetylate Tpm1 protein and regulate tropomyosin-actin interactions in budding yeast. Proc Natl Acad Sci U S A 100(13):7644-9
3) Polevoda B, et al.  (2003) Nat3p and Mdm20p are required for function of yeast NatB Nalpha-terminal acetyltransferase and of actin and tropomyosin. J Biol Chem 278(33):30686-97
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41