MET22/YOL064C Protein Information

Standard Name	Met22p 1
Systematic Name	Yol064cp
Alias	Hal2p
ORF Classification	Verified
Description	Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway (2)
Name Description	METhionine requiring 1
Gene Product	3'(2')5'-bisphosphate nucleotidase 2

Experimental Data
Molecules/cell	7330 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	357
Molecular Weight (Da)	39,149
Isoelectric Point (pI)	6.14

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Met22p (InterPro)
Physical Interactions	There are 3 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001120E7 \| P32179 MIPS: YOL064C NCBI: 1419883 \| 16974874 \| 16974875 \| 16974876 \| 16974877 \| 298023 \| 40786813 \| 417107 \| 6324508 \| 7245969 \| NP_014577.1 GenBank/EMBL/DDBJ: DAA10719.1 \| AY500154 \| X72847 \| Z74806
External Classifications	EC: 3.1.3.7 [3'(2'),5'-bisphosphate nucleotidase]

Amino Acid Sequence (or in FASTA format)
1 MALERELLVA TQAVRKASLL TKRIQSEVIS HKDSTTITKN DNSPVTTGDY 51 AAQTIIINAI KSNFPDDKVV GEESSSGLSD AFVSGILNEI KANDEVYNKN 101 YKKDDFLFTN DQFPLKSLED VRQIIDFGNY EGGRKGRFWC LDPIDGTKGF 151 LRGEQFAVCL ALIVDGVVQL GCIGCPNLVL SSYGAQDLKG HESFGYIFRA 201 VRGLGAFYSP SSDAESWTKI HVRHLKDTKD MITLEGVEKG HSSHDEQTAI 251 KNKLNISKSL HLDSQAKYCL LALGLADVYL RLPIKLSYQE KIWDHAAGNV 301 IVHEAGGIHT DAMEDVPLDF GNGRTLATKG VIASSGPREL HDLVVSTSCD 351 VIQSRNA*

Amino Acid Sequence (or in FASTA format)

       1  MALERELLVA TQAVRKASLL TKRIQSEVIS HKDSTTITKN DNSPVTTGDY
      51  AAQTIIINAI KSNFPDDKVV GEESSSGLSD AFVSGILNEI KANDEVYNKN
     101  YKKDDFLFTN DQFPLKSLED VRQIIDFGNY EGGRKGRFWC LDPIDGTKGF
     151  LRGEQFAVCL ALIVDGVVQL GCIGCPNLVL SSYGAQDLKG HESFGYIFRA
     201  VRGLGAFYSP SSDAESWTKI HVRHLKDTKD MITLEGVEKG HSSHDEQTAI
     251  KNKLNISKSL HLDSQAKYCL LALGLADVYL RLPIKLSYQE KIWDHAAGNV
     301  IVHEAGGIHT DAMEDVPLDF GNGRTLATKG VIASSGPREL HDLVVSTSCD
     351  VIQSRNA*

external links for Met22p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Met22p

1)	Masselot M and De Robichon-Szulmajster H (1975) Methionine biosynthesis in Saccharomyces cerevisiae. I. Genetical analysis of auxotrophic mutants. Mol Gen Genet 139(2):121-32
2)	Murguia JR, et al. (1996) The yeast HAL2 nucleotidase is an in vivo target of salt toxicity. J Biol Chem 271(46):29029-33
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41