RRT8/YOL048C Protein Information

Standard Name	Rrt8p 1
Systematic Name	Yol048cp
ORF Classification	Verified
Description	Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress (1, 2, 3, 4)
Name Description	Regulator of rDNA Transcription 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	342
Molecular Weight (Da)	39,600
Isoelectric Point (pI)	10.66

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rrt8p (InterPro)
Transmembrane Domains	There are 5 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 1 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001D47A6 \| Q08219 MIPS: YOL048C NCBI: 1419852 \| 30025647 \| 37362693 \| 84027752 \| NP_014594.2 GenBank/EMBL/DDBJ: DAA10735.1 \| AY245791 \| Z74790

Amino Acid Sequence (or in FASTA format)
1 MKAGIELISH SQASHATYAN SMTLAEKGPQ RLKRQFKEHS SSKESNVSRW 51 LKIFIRQFDI WFPETIPTMK VRYELLRKNF IKEIFNSRAF IYPFLGFYEV 101 LTNPVYWKHI LLFAVCYALI FVTIAGLFYV TLVPLLVTWA ILLLGPLGVI 151 LVHIQWILQT NVLTAFVCRT LVLTHITNQI FDISLVLQDQ DEFLNEVKVL 201 PKPQKPHRKI DEPDAVRNFN TIKGSRIFKI PRLLFRMFFK VSNFTSLTLL 251 SLIPIVGPIL ANQLMAPKRT FTYLQRYFLL KGFSKKQAKD FQYEHYASFI 301 CFGMSAGLLE LIPFFTIVTI SSNTVGAAKW CTSLLKGERK KE*

Amino Acid Sequence (or in FASTA format)

       1  MKAGIELISH SQASHATYAN SMTLAEKGPQ RLKRQFKEHS SSKESNVSRW
      51  LKIFIRQFDI WFPETIPTMK VRYELLRKNF IKEIFNSRAF IYPFLGFYEV
     101  LTNPVYWKHI LLFAVCYALI FVTIAGLFYV TLVPLLVTWA ILLLGPLGVI
     151  LVHIQWILQT NVLTAFVCRT LVLTHITNQI FDISLVLQDQ DEFLNEVKVL
     201  PKPQKPHRKI DEPDAVRNFN TIKGSRIFKI PRLLFRMFFK VSNFTSLTLL
     251  SLIPIVGPIL ANQLMAPKRT FTYLQRYFLL KGFSKKQAKD FQYEHYASFI
     301  CFGMSAGLLE LIPFFTIVTI SSNTVGAAKW CTSLLKGERK KE*

external links for Rrt8p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome
YGOB	GeneMANIA
YOGY

References cited on this page View Complete Literature Guide for Rrt8p

1)	Hontz RD, et al. (2009) Genetic Identification of Factors That Modulate Ribosomal DNA Transcription in Saccharomyces cerevisiae. Genetics 182(1):105-19
2)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3)	SGD (2006) No information available
4)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76