PRE6/YOL038W Protein Information Help

Standard Name Pre6p
Systematic Name Yol038wp
ORF Classification Verified
Description Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress (1, 2, 3)
Name Description PRoteinase yscE
Experimental Data
Molecules/cell 16800 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 254
Molecular Weight (Da) 28,439
Isoelectric Point (pI) 7.37

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Pre6p (InterPro)
Physical Interactions There are 144 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052FDF | P40303
MIPS: YOL038W
NCBI: 11513994 | 1419833 | 298508225 | 3114272 | 511905 | 6324535 | 730374 | NP_014604.1 | NM_001183292.1
GenBank/EMBL/DDBJ: AAA34903.1 | CAA99040.1 | DAA10745.1 | L34348 | Z74780
External Classifications EC: 3.4.25.1 [Proteasome endopeptidase complex]
Amino Acid Sequence (or in FASTA format)
       1  MSGYDRALSI FSPDGHIFQV EYALEAVKRG TCAVGVKGKN CVVLGCERRS
      51  TLKLQDTRIT PSKVSKIDSH VVLSFSGLNA DSRILIEKAR VEAQSHRLTL
     101  EDPVTVEYLT RYVAGVQQRY TQSGGVRPFG VSTLIAGFDP RDDEPKLYQT
     151  EPSGIYSSWS AQTIGRNSKT VREFLEKNYD RKEPPATVEE CVKLTVRSLL
     201  EVVQTGAKNI EITVVKPDSD IVALSSEEIN QYVTQIEQEK QEQQEQDKKK
     251  KSNH*                                                 

external links for Pre6p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) CYC2008 (complexes) MIPS YeastGFP
Candida (CGD) Complexome Pfam domains YeastRC Public Image Repository
YGOB DIP YeastRC Structure Prediction (Seattle)
YOGY GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Pre6p
1) Heinemeyer W, et al.  (1994) PRE5 and PRE6, the last missing genes encoding 20S proteasome subunits from yeast? Indication for a set of 14 different subunits in the eukaryotic proteasome core. Biochemistry 33(40):12229-37
2) Rinnerthaler M, et al.  (2006) MMI1 (YKL056c, TMA19), the yeast orthologue of the translationally controlled tumor protein (TCTP) has apoptotic functions and interacts with both microtubules and mitochondria. Biochim Biophys Acta 1757(5-6):631-8
3) Kusmierczyk AR, et al.  (2008) A multimeric assembly factor controls the formation of alternative 20S proteasomes. Nat Struct Mol Biol 15(3):237-44
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41