HTZ1/YOL012C Protein Information Help

Standard Name Htz1p 1
Systematic Name Yol012cp
Alias Hta3p 2
ORF Classification Verified
Description Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin (2, 3, 4, 5)
Name Description Histone Two A Z1 1
Gene Product H2A.F/Z 2 , H2AZ
Experimental Data
Molecules/cell 2840 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 134
Molecular Weight (Da) 14,283
Isoelectric Point (pI) 11.41

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Htz1p (InterPro)
Physical Interactions There are 233 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000053287 | Q12692
MIPS: YOL012C
NCBI: 1419783 | 188595808 | 2495139 | 45269890 | 6324562 | NP_014631.1
GenBank/EMBL/DDBJ: DAA10771.1 | AY558000 | Z74754
Amino Acid Sequence (or in FASTA format)
 
       1  MSGKAHGGKG KSGAKDSGSL RSQSSSARAG LQFPVGRIKR YLKRHATGRT
      51  RVGSKAAIYL TAVLEYLTAE VLELAGNAAK DLKVKRITPR HLQLAIRGDD
     101  ELDSLIRATI ASGGVLPHIN KALLLKVEKK GSKK*

external links for Htz1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Htz1p
1) Santisteban MS, et al.  (2000) Histone H2A.Z regulats transcription and is partially redundant with nucleosome remodeling complexes. Cell 103(3):411-22
2) Jackson JD, et al.  (1996) A likely histone H2A.F/Z variant in Saccharomyces cerevisiae. Trends Biochem Sci 21(12):466-7
3) Meneghini MD, et al.  (2003) Conserved histone variant H2A.Z protects euchromatin from the ectopic spread of silent heterochromatin. Cell 112(5):725-36
4) Krogan NJ, et al.  (2003) A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Mol Cell 12(6):1565-76
5) Mizuguchi G, et al.  (2004) ATP-driven exchange of histone H2AZ variant catalyzed by SWR1 chromatin remodeling complex. Science 303(5656):343-8
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41