SIN3/YOL004W Protein Information 
| Standard Name | Sin3p 1 |
|---|---|
| Systematic Name | Yol004wp |
| Alias | Cpe1p 2 , Gam2p 3 , Rpd1p 4, 5 , Sdi1p 4, 6 , Sds16p 7, 8 , Ume4p 4, 9 |
| ORF Classification | Verified |
| Description | Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity (10, 11) |
| Name Description | Switch INdependent |
| Experimental Data | |
|---|---|
| Molecules/cell | 1660 12 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Sin3p (InterPro) |
| Physical Interactions | There are 191 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI0000052F61 | P22579 MIPS: YOL004W NCBI: 1419767 | 172094 | 2507475 | 6324570 | NP_014639.1 GenBank/EMBL/DDBJ: DAA10779.1 | M36822 | Z74746 |
external links for Sin3p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | Organelle DB |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YPL+ |
| Aspergillus (AspGD) | BioPIXIE | MIPS | YeastGFP |
| Candida (CGD) | CYC2008 (complexes) | Pfam domains | YeastRC Public Image Repository |
| Candida (CandidaDB) | Complexome | YeastRC Structure Prediction (Seattle) | |
| YGOB | DIP | ||
| YOGY | GeneMANIA |
References cited on this page View Complete Literature Guide for Sin3p
| 1) | Sternberg PW, et al. (1987) Activation of the yeast HO gene by release from multiple negative controls. Cell 48(4):567-77 |
| 2) | Hudak KA, et al. (1994) A pleiotropic phospholipid biosynthetic regulatory mutation in Saccharomyces cerevisiae is allelic to sin3 (sdi1, ume4, rpd1). Genetics 136(2):475-83 |
| 3) | Yoshimoto H, et al. (1992) The Saccharomyces cerevisiae GAM2/SIN3 protein plays a role in both activation and repression of transcription. Mol Gen Genet 233(1-2):327-30 |
| 4) | Vidal M, et al. (1991) RPD1 (SIN3/UME4) is required for maximal activation and repression of diverse yeast genes. Mol Cell Biol 11(12):6306-16 |
| 5) | Vidal M, et al. (1990) Direct selection for mutants with increased K+ transport in Saccharomyces cerevisiae. Genetics 125(2):313-20 |
| 6) | Nasmyth K, et al. (1987) Both positive and negative regulators of HO transcription are required for mother-cell-specific mating-type switching in yeast. Cell 48(4):579-87 |
| 7) | Vannier D, et al. (1996) Evidence that the transcriptional regulators SIN3 and RPD3, and a novel gene (SDS3) with similar functions, are involved in transcriptional silencing in S. cerevisiae. Genetics 144(4):1343-53 |
| 8) | Sussel L, et al. (1995) Suppressors of defective silencing in yeast: effects on transcriptional repression at the HMR locus, cell growth and telomere structure. Genetics 141(3):873-88 |
| 9) | Strich R, et al. (1989) Identification of negative regulatory genes that govern the expression of early meiotic genes in yeast. Proc Natl Acad Sci U S A 86(24):10018-22 |
| 10) | Bernstein BE, et al. (2000) Genomewide studies of histone deacetylase function in yeast. Proc Natl Acad Sci U S A 97(25):13708-13 |
| 11) | Silverstein RA and Ekwall K (2005) Sin3: a flexible regulator of global gene expression and genome stability. Curr Genet 47(1):1-17 |
| 12) | Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41 |
