POP2/YNR052C Protein Information Help

Standard Name Pop2p 1
Systematic Name Ynr052cp
Alias Caf1p
ORF Classification Verified
Description RNase of the DEDD superfamily; subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation (2, 3, 4)
Name Description PGK promoter directed OverProduction 1
Experimental Data
Molecules/cell 1520 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 433
Molecular Weight (Da) 49,682
Isoelectric Point (pI) 6.11

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Pop2p (InterPro)
Physical Interactions There are 138 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052DFA | P39008
MIPS: YNR052C
NCBI: 1302568 | 1709720 | 172080 | 218463 | 218465 | 39654971 | 398365813 | 422919281 | 422919284 | 51013035 | NP_014450.3 | NM_001183229.3
GenBank/EMBL/DDBJ: AAA34832.1 | AAT92811.1 | BAA02246.1 | BAA02247.1 | CAA96333.1 | DAA10593.1 | AY692792 | D12807 | D12808 | M88607 | Z71667
External Classifications EC: 3.1.13.4 [Poly(A)-specific ribonuclease]
Amino Acid Sequence (or in FASTA format)
       1  MQSMNVQPRV LAVGGEQFFS QRQASEQHQQ QNMGPQVYSP KVNRARMFPQ
      51  GMPVNTINGS VNQEMNNAYL LKQKNEPLLT QQQQQQQQQQ QPFNIGTPVS
     101  VASLPPGLNV LQQQQQQQQQ QQQQQQGVGL NRPLASQLPK HLTNQSMPPI
     151  FLPPPNYLFV RDVWKSNLYS EFAVIRQLVS QYNHVSISTE FVGTLARPIG
     201  TFRSKVDYHY QTMRANVDFL NPIQLGLSLS DANGNKPDNG PSTWQFNFEF
     251  DPKKEIMSTE SLELLRKSGI NFEKHENLGI DVFEFSQLLM DSGLMMDDSV
     301  TWITYHAAYD LGFLINILMN DSMPNNKEDF EWWVHQYMPN FYDLNLVYKI
     351  IQEFKNPQLQ QSSQQQQQQQ YSLTTLADEL GLPRFSIFTT TGGQSLLMLL
     401  SFCQLSKLSM HKFPNGTDFA KYQGVIYGID GDQ*                 

external links for Pop2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily LoQate
Ashbya (AGD) BOND GPMdb (Mass Spec.) Organelle DB
Candida (CGD) CYC2008 (complexes) MIPS YPL+
YGOB Complexome Pfam domains YeastGFP
YOGY DIP YeastRC Structure Prediction (Seattle) YeastRC Public Image Repository

GeneMANIA


IMP


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Pop2p
1) Sakai A, et al.  (1992) Molecular analysis of POP2 gene, a gene required for glucose-derepression of gene expression in Saccharomyces cerevisiae. Nucleic Acids Res 20(23):6227-33
2) Tucker M, et al.  (2002) Ccr4p is the catalytic subunit of a Ccr4p/Pop2p/Notp mRNA deadenylase complex in Saccharomyces cerevisiae. EMBO J 21(6):1427-36
3) Daugeron MC, et al.  (2001) The yeast POP2 gene encodes a nuclease involved in mRNA deadenylation. Nucleic Acids Res 29(12):2448-55
4) Thore S, et al.  (2003) X-ray structure and activity of the yeast Pop2 protein: a nuclease subunit of the mRNA deadenylase complex. EMBO Rep 4(12):1150-5
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41