LYS9/YNR050C Protein Information

Standard Name	Lys9p
Systematic Name	Ynr050cp
Alias	Lys13p
ORF Classification	Verified
Description	Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112 (1, 2)
Name Description	LYSine requiring

Experimental Data
Molecules/cell	57500 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	446
Molecular Weight (Da)	48,917
Isoelectric Point (pI)	4.95

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Lys9p (InterPro)
Physical Interactions	There are 16 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052EEB \| P38999 MIPS: YNR050C NCBI: 114793467 \| 1302564 \| 453186 \| 51013871 \| 6324378 \| 729968 \| NP_014448.1 GenBank/EMBL/DDBJ: DAA10591.1 \| AY693210 \| X77363 \| Z71665
External Classifications	EC: 1.5.1.10 [Saccharopine dehydrogenase (NADP(+), L-glutamate-forming)]

Amino Acid Sequence (or in FASTA format)
1 MGKNVLLLGS GFVAQPVIDT LAANDDINVT VACRTLANAQ ALAKPSGSKA 51 ISLDVTDDSA LDKVLADNDV VISLIPYTFH PNVVKSAIRT KTDVVTSSYI 101 SPALRELEPE IVKAGITVMN EIGLDPGIDH LYAVKTIDEV HRAGGKLKSF 151 LSYCGGLPAP EDSDNPLGYK FSWSSRGVLL ALRNSAKYWK DGKIETVSSE 201 DLMATAKPYF IYPGYAFVCY PNRDSTLFKD LYHIPEAETV IRGTLRYQGF 251 PEFVKALVDM GMLKDDANEI FSKPIAWNEA LKQYLGAKST SKEDLIASID 301 SKATWKDDED RERILSGFAW LGLFSDAKIT PRGNALDTLC ARLEELMQYE 351 DNERDMVVLQ HKFGIEWADG TTETRTSTLV DYGKVGGYSS MAATVGYPVA 401 IATKFVLDGT IKGPGLLAPY SPEINDPIMK ELKDKYGIYL KEKTVA*

Amino Acid Sequence (or in FASTA format)

       1  MGKNVLLLGS GFVAQPVIDT LAANDDINVT VACRTLANAQ ALAKPSGSKA
      51  ISLDVTDDSA LDKVLADNDV VISLIPYTFH PNVVKSAIRT KTDVVTSSYI
     101  SPALRELEPE IVKAGITVMN EIGLDPGIDH LYAVKTIDEV HRAGGKLKSF
     151  LSYCGGLPAP EDSDNPLGYK FSWSSRGVLL ALRNSAKYWK DGKIETVSSE
     201  DLMATAKPYF IYPGYAFVCY PNRDSTLFKD LYHIPEAETV IRGTLRYQGF
     251  PEFVKALVDM GMLKDDANEI FSKPIAWNEA LKQYLGAKST SKEDLIASID
     301  SKATWKDDED RERILSGFAW LGLFSDAKIT PRGNALDTLC ARLEELMQYE
     351  DNERDMVVLQ HKFGIEWADG TTETRTSTLV DYGKVGGYSS MAATVGYPVA
     401  IATKFVLDGT IKGPGLLAPY SPEINDPIMK ELKDKYGIYL KEKTVA*

external links for Lys9p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Lys9p

1)	Storts DR and Bhattacharjee JK (1987) Purification and properties of saccharopine dehydrogenase (glutamate forming) in the Saccharomyces cerevisiae lysine biosynthetic pathway. J Bacteriol 169(1):416-8
2)	Studte P, et al. (2008) tRNA and protein methylase complexes mediate zymocin toxicity in yeast. Mol Microbiol 69(5):1266-77
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41