AGA1/YNR044W Protein Information Help

Standard Name Aga1p
Systematic Name Ynr044wp
ORF Classification Verified
Description Anchorage subunit of a-agglutinin of a-cells; highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds; AGA1 has a paralog, FIG2, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description a cell-specific sexual AGglutination
Gene Product a-agglutinin anchorage subunit 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 725
Molecular Weight (Da) 73,353
Isoelectric Point (pI) 4.5

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Aga1p (InterPro)
Signal Peptide(s) There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions There are 4 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001256A1 | P32323
MIPS: YNR044W
NCBI: 1302552 | 170964 | 416592 | 6324372 | NP_014442.1 | NM_001183221.1
GenBank/EMBL/DDBJ: DAA10585.1 | M60590 | Z71659
Amino Acid Sequence (or in FASTA format)
 
       1  MTLSFAHFTY LFTILLGLTN IALASDPETI LVTITKTNDA NGVVTTTVSP
      51  ALVSTSTIVQ AGTTTLYTTW CPLTVSTSSA AEISPSISYA TTLSRFSTLT
     101  LSTEVCSHEA CPSSSTLPTT TLSVTSKFTS YICPTCHTTA ISSLSEVGTT
     151  TVVSSSAIEP SSASIISPVT STLSSTTSSN PTTTSLSSTS TSPSSTSTSP
     201  SSTSTSSSST STSSSSTSTS SSSTSTSPSS TSTSSSLTST SSSSTSTSQS
     251  STSTSSSSTS TSPSSTSTSS SSTSTSPSSK STSASSTSTS SYSTSTSPSL
     301  TSSSPTLAST SPSSTSISST FTDSTSSLGS SIASSSTSVS LYSPSTPVYS
     351  VPSTSSNVAT PSMTSSTVET TVSSQSSSEY ITKSSISTTI PSFSMSTYFT
     401  TVSGVTTMYT TWCPYSSESE TSTLTSMHET VTTDATVCTH ESCMPSQTTS
     451  LITSSIKMST KNVATSVSTS TVESSYACST CAETSHSYSS VQTASSSSVT
     501  QQTTSTKSWV SSMTTSDEDF NKHATGKYHV TSSGTSTIST SVSEATSTSS
     551  IDSESQEQSS HLLSTSVLSS SSLSATLSSD STILLFSSVS SLSVEQSPVT
     601  TLQISSTSEI LQPTSSTAIA TISASTSSLS ATSISTPSTS VESTIESSSL
     651  TPTVSSIFLS SSSAPSSLQT SVTTTEVSTT SISIQYQTSS MVTISQYMGS
     701  GSQTRLPLGK LVFAIMAVAC NVIFS*

external links for Aga1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

GeneMANIA

References cited on this page View Complete Literature Guide for Aga1p
1) Roy A, et al.  (1991) The AGA1 product is involved in cell surface attachment of the Saccharomyces cerevisiae cell adhesion glycoprotein a-agglutinin. Mol Cell Biol 11(8):4196-206
2) de Nobel H, et al.  (1995) Genetics of a-agglutunin function in Saccharomyces cerevisiae. Mol Gen Genet 247(4):409-15
3) Zhao H, et al.  (2001) Interaction of alpha-agglutinin and a-agglutinin, Saccharomyces cerevisiae sexual cell adhesion molecules. J Bacteriol 183(9):2874-80
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61