ZRG17/YNR039C Protein Information

Standard Name	Zrg17p 1
Systematic Name	Ynr039cp
ORF Classification	Verified
Description	Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Msc2p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; zinc-regulated directly through Zap1p; transcription induced under conditions of zinc deficiency (1, 2, 3)
Name Description	Zinc Regulated Gene 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	605
Molecular Weight (Da)	67,460
Isoelectric Point (pI)	7.14

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Zrg17p (InterPro)
Transmembrane Domains	There are 6 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 13 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013BABE \| P53735 MIPS: YNR039C NCBI: 1302543 \| 1730679 \| 51013661 \| 6324367 \| NP_014437.1 GenBank/EMBL/DDBJ: DAA10581.1 \| AY693105 \| Z71654

Amino Acid Sequence (or in FASTA format)
1 METPQMNAIQ EEDNLSPEVA FQTPKLNDSD ASSFSLSNMN AVGNVDGIPS 51 QNRTFFASPR PSSLFYSAKE GNNSSSSIIY NPSFTFGENA SSNANINEAA 101 LMKGKGNEGR RQSLKYIPAP KLVPPPPRTR SPVRGISPDA GSSKRSSMTL 151 DSPFNFTTST LQPHQQTPPS SAASRTSFRK GHRYKHSSVS MNFFQEPEVK 201 IPLNIAKSLP IPDFNDLLSN LPWPKAYIQL SIAALQIFAC LITFQVGHLY 251 SWSNFITLSH FITYDIIGSL VIIFVENLSQ FQVWFTGTIT FPFGLNRIDV 301 LLSFALAVSL CFVGLDLLFH IIEEFIVLFV ESGSSLTNNH DHDEINEQIP 351 HSHIANANDS QNENITLWYS ILMINLVLST LSLYKTFYAN KYSNLKTKNP 401 IITITYTAYL FIYPLLLDLL SSISDYLATL VISSLILWHG LTIARWTSTV 451 LLMGFSTTSL SNSALFNNND STDTTAHTQQ VESKAAKEKP SVRPRSMSSL 501 PIATKNTKIR KTGFLNSAGF TENPTTIKNM IKDQIERLSE FKSRYILNYD 551 DIVISKVNFT LYVVLIKITM KGGSDDDELM LRLAIDKCIQ TSIPTCETTI 601 DIDRI*

Amino Acid Sequence (or in FASTA format)

       1  METPQMNAIQ EEDNLSPEVA FQTPKLNDSD ASSFSLSNMN AVGNVDGIPS
      51  QNRTFFASPR PSSLFYSAKE GNNSSSSIIY NPSFTFGENA SSNANINEAA
     101  LMKGKGNEGR RQSLKYIPAP KLVPPPPRTR SPVRGISPDA GSSKRSSMTL
     151  DSPFNFTTST LQPHQQTPPS SAASRTSFRK GHRYKHSSVS MNFFQEPEVK
     201  IPLNIAKSLP IPDFNDLLSN LPWPKAYIQL SIAALQIFAC LITFQVGHLY
     251  SWSNFITLSH FITYDIIGSL VIIFVENLSQ FQVWFTGTIT FPFGLNRIDV
     301  LLSFALAVSL CFVGLDLLFH IIEEFIVLFV ESGSSLTNNH DHDEINEQIP
     351  HSHIANANDS QNENITLWYS ILMINLVLST LSLYKTFYAN KYSNLKTKNP
     401  IITITYTAYL FIYPLLLDLL SSISDYLATL VISSLILWHG LTIARWTSTV
     451  LLMGFSTTSL SNSALFNNND STDTTAHTQQ VESKAAKEKP SVRPRSMSSL
     501  PIATKNTKIR KTGFLNSAGF TENPTTIKNM IKDQIERLSE FKSRYILNYD
     551  DIVISKVNFT LYVVLIKITM KGGSDDDELM LRLAIDKCIQ TSIPTCETTI
     601  DIDRI*

external links for Zrg17p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Zrg17p

1)	Yuan DS (2000) Zinc-regulated genes in Saccharomyces cerevisiae revealed by transposon tagging. Genetics 156(1):45-58
2)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3)	Cyert MS and Philpott CC (2013) Regulation of Cation Balance in Saccharomyces cerevisiae. Genetics 193(3):677-713