SNF12/YNR023W Protein Information Help

Standard Name Snf12p 1
Systematic Name Ynr023wp
Alias Swp73p 2, 3
ORF Classification Verified
Description 73 kDa subunit of the SWI/SNF chromatin remodeling complex; involved in transcriptional regulation; relocates to the cytosol under hypoxic conditions; deletion mutants are temperature-sensitive; SNF12 has a paralog, RSC6, that arose from the whole genome duplication (1, 2, 4, 5, 6, 7)
Name Description Sucrose NonFermenting 8
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 566
Molecular Weight (Da) 63,870
Isoelectric Point (pI) 5.5

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Snf12p (InterPro)
Physical Interactions There are 58 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052FCC | P53628
MIPS: YNR023W
NCBI: 1302512 | 1711619 | 4107 | 6324350 | NP_014420.1
GenBank/EMBL/DDBJ: DAA10564.1 | X62430 | Z71638
Amino Acid Sequence (or in FASTA format)
 
       1  MSKVMKPSNG KGSRKSSKAA TPDTKNFFHA KKKDPVNQDK ANNASQITPT
      51  VPHSHPSDMV IPDHLAELIP ELYSFQQLVD SEKRLDHFIH LRNLHMKRMV
     101  AQWERSKLSQ EFLYPHLNFP NVKFLRIFIS NVSENQPWQM DTNNEADLMA
     151  LENATWTMRI EGRLLDNVQA NDPAREKFSS FIESIVVDFK NKENDNVPST
     201  KFNAAPEENA TEGPSDKKLN LNLPLQFSLP NGDNSTTTNT DQNNATMGEE
     251  TAKKDMSSTT PKLESVKWQY DPNNPVDFDG LDIKRVGSEN VECTISILRK
     301  SSPEEPFMSY SPQLTAIIGL KSGTSHDAIF SIYKYIHLNE LLTNDESAFE
     351  NLMGNRNNHN SNTSTSKMLD AASSQVSIVK LDTQLITLLP SSLKESSPDT
     401  MKLTDLLSLI NSTHLLPLQP IEIDYTVRVD KASTYGELVL DIEVPDVNAL
     451  KFNNTQRESQ IGAAELNENA RELEQIKPKI ALQDKEITSV LSNLHESNKR
     501  YRFFKKISED PVKALNECIA STSNALKVLS GDEGYNEDMV RRANFYKENE
     551  AMLRENIEVI LSNGRM*

external links for Snf12p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Snf12p
1) Miller ME, et al.  (1996) Adenovirus E1A specifically blocks SWI/SNF-dependent transcriptional activation. Mol Cell Biol 16(10):5737-43
2) Cairns BR, et al.  (1996) Essential role of Swp73p in the function of yeast Swi/Snf complex. Genes Dev 10(17):2131-44
3) Cairns BR, et al.  (1994) A multisubunit complex containing the SWI1/ADR6, SWI2/SNF2, SWI3, SNF5, and SNF6 gene products isolated from yeast. Proc Natl Acad Sci U S A 91(5):1950-4
4) Cairns BR, et al.  (1996) RSC, an essential, abundant chromatin-remodeling complex. Cell 87(7):1249-60
5) Sudarsanam P and Winston F  (2000) The Swi/Snf family nucleosome-remodeling complexes and transcriptional control. Trends Genet 16(8):345-51
6) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
7) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30
8) Carlson M, et al.  (1981) Mutants of yeast defective in sucrose utilization. Genetics 98(1):25-40