TIM23/YNR017W Protein Information

Standard Name	Tim23p 1
Systematic Name	Ynr017wp
Alias	Mim23p , Mpi3p 2 , Mas6p 3
ORF Classification	Verified
Description	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel (3, 4, 5)
Name Description	Translocase of the Inner Mitochondrial membrane 1

Experimental Data
Molecules/cell	1440 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	222
Molecular Weight (Da)	23,243
Isoelectric Point (pI)	7.43

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Tim23p (InterPro)
Physical Interactions	There are 207 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012D5DE \| P32897 MIPS: YNR017W NCBI: 1302500 \| 297118 \| 398365641 \| 402785 \| 417274 \| NP_014414.3 GenBank/EMBL/DDBJ: DAA10558.1 \| X71633 \| X74161 \| Z71632

Amino Acid Sequence (or in FASTA format)
1 MSWLFGDKTP TDDANAAVGG QDTTKPKELS LKQSLGFEPN INNIISGPGG 51 MHVDTARLHP LAGLDKGVEY LDLEEEQLSS LEGSQGLIPS RGWTDDLCYG 101 TGAVYLLGLG IGGFSGMMQG LQNIPPNSPG KLQLNTVLNH ITKRGPFLGN 151 NAGILALSYN IINSTIDALR GKHDTAGSIG AGALTGALFK SSKGLKPMGY 201 SSAMVAAACA VWCSVKKRLL EK*

Amino Acid Sequence (or in FASTA format)

       1  MSWLFGDKTP TDDANAAVGG QDTTKPKELS LKQSLGFEPN INNIISGPGG
      51  MHVDTARLHP LAGLDKGVEY LDLEEEQLSS LEGSQGLIPS RGWTDDLCYG
     101  TGAVYLLGLG IGGFSGMMQG LQNIPPNSPG KLQLNTVLNH ITKRGPFLGN
     151  NAGILALSYN IINSTIDALR GKHDTAGSIG AGALTGALFK SSKGLKPMGY
     201  SSAMVAAACA VWCSVKKRLL EK*

external links for Tim23p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Tim23p

1)	Pfanner N, et al. (1996) Uniform nomenclature for the protein transport machinery of the mitochondrial membranes. Trends Biochem Sci 21(2):51-2
2)	Dekker PJ, et al. (1993) Identification of MIM23, a putative component of the protein import machinery of the mitochondrial inner membrane. FEBS Lett 330(1):66-70
3)	Emtage JL and Jensen RE (1993) MAS6 encodes an essential inner membrane component of the yeast mitochondrial protein import pathway. J Cell Biol 122(5):1003-12
4)	Truscott KN, et al. (2001) A presequence- and voltage-sensitive channel of the mitochondrial preprotein translocase formed by Tim23. Nat Struct Biol 8(12):1074-82
5)	Martinez-Caballero S, et al. (2007) Tim17p regulates the twin pore structure and voltage gating of the mitochondrial protein import complex TIM23. J Biol Chem 282(6):3584-93
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41