URK1/YNR012W Protein Information

Standard Name	Urk1p 1
Systematic Name	Ynr012wp
ORF Classification	Verified
Description	Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP (2, 3, 4)
Name Description	URidine Kinase 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	501
Molecular Weight (Da)	56,296
Isoelectric Point (pI)	7.69

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Urk1p (InterPro)
Physical Interactions	There are 16 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000004C56C \| P27515 MIPS: YNR012W NCBI: 1302490 \| 137110 \| 4773 \| 496728 \| 6324339 \| NP_014409.1 GenBank/EMBL/DDBJ: DAA10553.1 \| X53998 \| X77395 \| Z71627
External Classifications	EC: 2.7.1.48 [Uridine kinase] EC: 2.7.1.74 [Deoxycytidine kinase]

Amino Acid Sequence (or in FASTA format)
1 MSHRIAPSKE RSSSFISILD DETRDTLKAN AVMDGEVDVK KTKGKSSRYI 51 PPWTTPYIIG IGGASGSGKT SVAAKIVSSI NVPWTVLISL DNFYNPLGPE 101 DRARAFKNEY DFDEPNAINL DLAYKCILNL KEGKRTNIPV YSFVHHNRVP 151 DKNIVIYGAS VVVIEGIYAL YDRRLLDLMD LKIYVDADLD VCLARRLSRD 201 IVSRGRDLDG CIQQWEKFVK PNAVKFVKPT MKNADAIIPS MSDNATAVNL 251 IINHIKSKLE LKSNEHLREL IKLGSSPSQD VLNRNIIHEL PPTNQVLSLH 301 TMLLNKNLNC ADFVFYFDRL ATILLSWALD DIPVAHTNII TPGEHTMENV 351 IACQFDQVTA VNIIRSGDCF MKSLRKTIPN ITIGKLLIQS DSQTGEPQLH 401 CEFLPPNIEK FGKVFLMEGQ IISGAAMIMA IQVLLDHGID LEKISVVVYL 451 ATEVGIRRIL NAFDNKVNIF AGMIISREKL QNHQYKWALT RFFDSKYFGC 501 D*

Amino Acid Sequence (or in FASTA format)

       1  MSHRIAPSKE RSSSFISILD DETRDTLKAN AVMDGEVDVK KTKGKSSRYI
      51  PPWTTPYIIG IGGASGSGKT SVAAKIVSSI NVPWTVLISL DNFYNPLGPE
     101  DRARAFKNEY DFDEPNAINL DLAYKCILNL KEGKRTNIPV YSFVHHNRVP
     151  DKNIVIYGAS VVVIEGIYAL YDRRLLDLMD LKIYVDADLD VCLARRLSRD
     201  IVSRGRDLDG CIQQWEKFVK PNAVKFVKPT MKNADAIIPS MSDNATAVNL
     251  IINHIKSKLE LKSNEHLREL IKLGSSPSQD VLNRNIIHEL PPTNQVLSLH
     301  TMLLNKNLNC ADFVFYFDRL ATILLSWALD DIPVAHTNII TPGEHTMENV
     351  IACQFDQVTA VNIIRSGDCF MKSLRKTIPN ITIGKLLIQS DSQTGEPQLH
     401  CEFLPPNIEK FGKVFLMEGQ IISGAAMIMA IQVLLDHGID LEKISVVVYL
     451  ATEVGIRRIL NAFDNKVNIF AGMIISREKL QNHQYKWALT RFFDSKYFGC
     501  D*

external links for Urk1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Urk1p

1)	Kern L (1990) The URK1 gene of Saccharomyces cerevisiae encoding uridine kinase. Nucleic Acids Res 18(17):5279
2)	Kurtz JE, et al. (1999) New insights into the pyrimidine salvage pathway of Saccharomyces cerevisiae: requirement of six genes for cytidine metabolism. Curr Genet 36(3):130-6
3)	Mitterbauer R, et al. (2002) Saccharomyces cerevisiae URH1 (encoding uridine-cytidine N-ribohydrolase): functional complementation by a nucleoside hydrolase from a protozoan parasite and by a mammalian uridine phosphorylase. Appl Environ Microbiol 68(3):1336-43
4)	Kurtz JE, et al. (2002) The URH1 uridine ribohydrolase of Saccharomyces cerevisiae. Curr Genet 41(3):132-41