COS1/YNL336W Protein Information

Standard Name	Cos1p
Systematic Name	Ynl336wp
ORF Classification	Verified
Description	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins (1, 2)
Name Description	COnserved Sequence

Experimental Data
Molecules/cell	1730 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	381
Molecular Weight (Da)	45,288
Isoelectric Point (pI)	8.53

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Cos1p (InterPro)
Transmembrane Domains	There are 4 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 5 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000127F2A \| P53822 MIPS: YNL336W NCBI: 1302463 \| 1730657 \| 6323993 \| NP_014063.1 GenBank/EMBL/DDBJ: DAA10227.1 \| Z71612

Amino Acid Sequence (or in FASTA format)
1 MKENELKNEK SVDVLSFKQL ESQKIVLPQD LFRSSFTWFC YEIYKSLAFR 51 IWMLLWLPLS VWWKLSNNCI YPLIVSLLVL FLGPIFVLVI CGLSRKRSLS 101 KQLIQFCKEV TENTPSSDPH DWEVVAANLN SYLYENKAWN TKYFFFNAMV 151 CQEAFRTTLL EPFSLKKDEA AKVKSFKDSV PYIEEALGVY FREVEKQWKL 201 FNSEKSWSPV GLEDAKLPKE AYRFKLTWFL KRISNIFMLI PFLNFLCCIY 251 VSRGMCLLLR TFYLGWILFM LVQGFQNMRM IVLSVKMEHK MQFLSTIINE 301 QESGANGWDE IAKKMNRYLF EKKVWKNEEF FFDGIDCEWF FSHFFYRVLS 351 AKKSMRALSL NVELWPYIKE AQLSCSEESL A*

Amino Acid Sequence (or in FASTA format)

       1  MKENELKNEK SVDVLSFKQL ESQKIVLPQD LFRSSFTWFC YEIYKSLAFR
      51  IWMLLWLPLS VWWKLSNNCI YPLIVSLLVL FLGPIFVLVI CGLSRKRSLS
     101  KQLIQFCKEV TENTPSSDPH DWEVVAANLN SYLYENKAWN TKYFFFNAMV
     151  CQEAFRTTLL EPFSLKKDEA AKVKSFKDSV PYIEEALGVY FREVEKQWKL
     201  FNSEKSWSPV GLEDAKLPKE AYRFKLTWFL KRISNIFMLI PFLNFLCCIY
     251  VSRGMCLLLR TFYLGWILFM LVQGFQNMRM IVLSVKMEHK MQFLSTIINE
     301  QESGANGWDE IAKKMNRYLF EKKVWKNEEF FFDGIDCEWF FSHFFYRVLS
     351  AKKSMRALSL NVELWPYIKE AQLSCSEESL A*

external links for Cos1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Cos1p

1)	Spode I, et al. (2002) ATF/CREB sites present in sub-telomeric regions of Saccharomyces cerevisiae chromosomes are part of promoters and act as UAS/URS of highly conserved COS genes. J Mol Biol 319(2):407-20
2)	Despons L, et al. (2006) An evolutionary scenario for one of the largest yeast gene families. Trends Genet 22(1):10-5
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41