THI12/YNL332W Protein Information

Standard Name	Thi12p 1
Systematic Name	Ynl332wp
ORF Classification	Verified
Description	Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 (2)
Name Description	THIamine metabolism

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	340
Molecular Weight (Da)	38,619
Isoelectric Point (pI)	8.08

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Thi12p (InterPro)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000136D0C \| P42883 MIPS: YNL332W NCBI: 1171742 \| 1302455 \| 6323997 \| 642336 \| NP_014067.1 \| NM_001183170.1 GenBank/EMBL/DDBJ: DAA10231.1 \| X83226 \| Z71608

Amino Acid Sequence (or in FASTA format)
1 MSTDKITFLL NWQPTPYHIP IFLAQTKGYF KEQGLDMAIL EPTNPSDVTE 51 LIGSGKVDMG LKAMIHTLAA KARGFPVTSV ASLLDEPFTG VLYLKGSGIT 101 EDFQSLKGKK IGYVGEFGKI QIDELTKHYG MKPEDYTAVR CGMNVAKYII 151 EGKIDAGIGI ECMQQVELEE YLAKQGRPAS DAKMLRIDKL ACLGCCCFCT 201 VLYICNDEFL KKNPEKVRKF LKAIKKATDY VLADPVKAWK EYIDFKPRLN 251 NDLSYKQYQR CYAYFSSSLY NVHRDWKKVT GYGKRLAILP PDYVSNYTNE 301 YLSWPEPEEV SDPLEAQRLM AIHQEKCRQE GTFKRLALPA *

Amino Acid Sequence (or in FASTA format)

       1  MSTDKITFLL NWQPTPYHIP IFLAQTKGYF KEQGLDMAIL EPTNPSDVTE
      51  LIGSGKVDMG LKAMIHTLAA KARGFPVTSV ASLLDEPFTG VLYLKGSGIT
     101  EDFQSLKGKK IGYVGEFGKI QIDELTKHYG MKPEDYTAVR CGMNVAKYII
     151  EGKIDAGIGI ECMQQVELEE YLAKQGRPAS DAKMLRIDKL ACLGCCCFCT
     201  VLYICNDEFL KKNPEKVRKF LKAIKKATDY VLADPVKAWK EYIDFKPRLN
     251  NDLSYKQYQR CYAYFSSSLY NVHRDWKKVT GYGKRLAILP PDYVSNYTNE
     301  YLSWPEPEEV SDPLEAQRLM AIHQEKCRQE GTFKRLALPA *

external links for Thi12p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	GeneMANIA

References cited on this page View Complete Literature Guide for Thi12p

1)	Hather, R.J. and P.A. Meacock (1996) Characterization of two new thiamine regulated Saccharomyces cerevisiae Genes, THI11 and THI12. Unpublished
2)	Wightman R and Meacock PA (2003) The THI5 gene family of Saccharomyces cerevisiae: distribution of homologues among the hemiascomycetes and functional redundancy in the aerobic biosynthesis of thiamin from pyridoxine. Microbiology 149(Pt 6):1447-60